Les lymphocytes T régulateurs et les lymphocytes Th17: Fonctions physiologiques et pathologiques

Translated title of the contribution: T regulator and Th17 lymphocytes: Physiological and pathological functions

Murielle Corvaisier-Chiron, Céline Beauvillain, Jeremy Hughes, Ashley Jefferson, E. Raynaud De Mauverger, Gabriel Fernandez, I. Lowy, D. Molrine, B. Vingert, S. Perez-Patrigeon, P. Jeannin, Y. Bourne, Z. Radic, R. Aráoz, A. Weeks, G. Alia, R. Clarke, J. Peden, C. Steidl, T. LeeS. Shah, S. Liang, H. Wang, K. Newell, A. Asare, A. Kirk, A. Studebaker, C. Kreofsky, C. Pierson, C. Lam, T. Yoo, B. Hiner

Research output: Contribution to journalArticlepeer-review

Abstract

Over two decades ago, CD4+ T cells were classified into various T cell subsets. Each subset is characterised by its specific cytokine pattern and effector functions in the immune response. This classification has long been confined to two subsets of helper T cells called Th1 and Th2 cells. Recently, new CD4+ T cell populations have been describe, including natural and inducible regulatory T cells and the proinflammatory Th17 cells. The discovery of these new populations provided a better understanding of the pathophysiology of various diseases, including chronic inflammatory disorders including some of autoimmune diseases, cancers and chronic infections. In this review, the generation of regulatory T cells and Th17 cells, the mechanisms used by these T cells to maintain the physiological balance between inflammatory and immunosuppressive immune responses, and their implication in physiopathology of various diseases will be discussed.

Translated title of the contributionT regulator and Th17 lymphocytes: Physiological and pathological functions
Original languageFrench
Pages (from-to)31-40
Number of pages10
JournalRevue Francophone des Laboratoires
Volume2010
Issue number424
DOIs
StatePublished - 2010

Keywords

  • Immune response
  • Th17 cells
  • auto-immune diseases
  • cancers
  • infectious diseases
  • regulatory T cells

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