Les cellules de la microglie leurs origines extraembryonnaires enfin révélées

Translated title of the contribution: Microglia arise from extra-embryonic yolk sac primitive progenitors

Florent Ginhoux, Miriam Merad

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Microglia are the resident macrophage population of the central nervous system (CNS). Adequate microglia function is crucial for the homeostasis of the CNS in health and disease, as they represent the first line of defence against pathogens, contributing to immune responses, but are also involved in tissue repair and remodeling. It is therefore crucial to better understand microglia origin and homeostasis. Much controversy remains regarding the nature of microglial progenitors, as the exact contribution and persistence of embryonic and postnatal hematopoietic progenitors to the adult microglial pool in the steady state remained unclear. In this study, we show that post-natal hematopoietic progenitors do not significantly contribute to microglia homeostasis in the adult brain in mice. In vivo lineage tracing studies established that adult microglia derives from primitive hematopoietic progenitors that arise before embryonic day 8. These results identify microglia as an ontogenically distinct population in the mononuclear phagocyte system and have implications for the use of embryonically-derived microglial progenitors for the treatment of various brain disorders.

Translated title of the contributionMicroglia arise from extra-embryonic yolk sac primitive progenitors
Original languageFrench
Pages (from-to)719-723
Number of pages5
JournalMedecine/Sciences
Volume27
Issue number8-9
DOIs
StatePublished - Aug 2011

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