Leptin predicts diabetes but not cardiovascular disease: Results from a large prospective study in an elderly population

Paul Welsh, Heather M. Murray, Brendan M. Buckley, Anton J.M. De Craen, Ian Ford, J. Wouter Jukema, Peter W. Macfarlane, Chris J. Packard, David J. Stott, Rudi G.J. Westendorp, James Shepherd, Naveed Sattar

Research output: Contribution to journalArticlepeer-review

76 Scopus citations

Abstract

OBJECTIVE - To clarify the association of circulating levels of leptin with risk for cardiovascular disease (CVD) events and new-onset diabetes in men and women. RESEARCH DESIGN AND METHODS - We related baseline leptin levels to CVD events (n = 864) and incident diabetes (n = 289) in an elderly population (n = 5,672) over 3.2 years of follow-up. RESULTS - In treatment-, age-, and country-adjusted models, leptin was not associated with risk of CVD in men (hazard ratio 1.02 [95% CI 0.90-1.16] per unit log-leptin increase) or women (1.05 [0.91-1.20]) but was associated with risk of diabetes in men (2.75 [2.14-3.52]) and women (1.54 [1.22-1.94]). After adjusting for classic risk factors and BMI, C-reactive protein, and glucose, the diabetes association retained significance in men (1.85 [1.30-2.63]) but not in women (0.89 [0.64-1.26]). CONCLUSIONS - Leptin, similar to other markers of adiposity in general, is more strongly related to risk of diabetes than CVD in the elderly.

Original languageEnglish
Pages (from-to)308-310
Number of pages3
JournalDiabetes Care
Volume32
Issue number2
DOIs
StatePublished - Feb 2009
Externally publishedYes

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