Left versus right hemisphere differences in brain connectivity: 4-Tesla HARDI tractography in 569 twins

Madelaine Daianu, Neda Jahanshad, Emily L. Dennis, Arthur W. Toga, Katie L. McMahon, Greig I. De Zubicaray, Nicholas G. Martin, Margaret J. Wright, Ian B. Hickie, Paul M. Thompson

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

14 Scopus citations

Abstract

Diffusion imaging can map anatomical connectivity in the living brain, offering new insights into fundamental questions such as how the left and right brain hemispheres differ. Anatomical brain asymmetries are related to speech and language abilities, but less is known about left/right hemisphere differences in brain wiring. To assess this, we scanned 457 young adults (age 23.4±2.0 SD years) and 112 adolescents (age 12-16) with 4-Tesla 105-gradient high-angular resolution diffusion imaging. We extracted fiber tracts throughout the brain with a Hough transform method. A 70×70 connectivity matrix was created, for each subject, based on the proportion of fibers intersecting 70 cortical regions. We identified significant differences in the proportions of fibers intersecting left and right hemisphere cortical regions. The degree of asymmetry in the connectivity matrices varied with age, as did the asymmetry in network topology measures such as the small-world effect.

Original languageEnglish
Title of host publication2012 9th IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro, ISBI 2012 - Proceedings
Pages526-529
Number of pages4
DOIs
StatePublished - 2012
Externally publishedYes
Event2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Barcelona, Spain
Duration: 2 May 20125 May 2012

Publication series

NameProceedings - International Symposium on Biomedical Imaging
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Conference

Conference2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012
Country/TerritorySpain
CityBarcelona
Period2/05/125/05/12

Keywords

  • connectome
  • high angular resolution diffusion imaging (HARDI)
  • laterality
  • small-world effect
  • tractography

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