Left Ventricular Pressure Volume Assessment Using Carotid Artery Access in the Rat

Spyros A. Mavropoulos, Kiyotake Ishikawa

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Left ventricular (LV) catheterization with either a pressure catheter or pressure–volume catheter provides a means to measure cardiac function, an important endpoint in many studies including cardiac gene therapy. While the catheter can be inserted directly into the heart using a surgical approach, utilizing the carotid artery for access has the advantage of being a closed-chest procedure. This negates the need for intubation, prevents myocardial trauma, and preserves normal intrathoracic pressure, providing more accurate assessments of cardiac physiology parameters. We describe a protocol for obtaining carotid artery access and insertion of a pressure–volume catheter into the LV of rodents.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages305-311
Number of pages7
DOIs
StatePublished - 2022

Publication series

NameMethods in Molecular Biology
Volume2573
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Cardiac function
  • Carotid artery catheterization
  • Left ventricle
  • PV loop
  • Pressure catheter

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