Left ventricular end-diastolic volume from ejection fraction and stroke volume in pigs during IVC occlusion

Cecily J. Gallup, Santos E. Cabreriza, Joseph P. Hart, Rowan Walsh, Alan Weinberg, Henry M. Spotnitz

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background. Real-time measurement of left ventricular end-diastolic volume (LVEDV), combined with left ventricular end-diastolic pressure (LVEDP), would allow continuous measurement of intraoperative diastolic function. In pursuit of this goal, we examined stroke volume divided by ejection fraction for calculation of LVEDVsv/ef. Methods. Five anesthetized pigs underwent median sternotomy and pericardiotomy. A transit-time ultrasonic flow probe on the ascending aorta provided cardiac output. A micromanometer provided LV end-diastolic pressure. End-diastolic and end-systolic areas were measured from LV short-axis cross sections to obtain ejection fraction. LVEDVsv/ef was calculated during IVC occlusion. Steady-state LVEDVecho was determined using a three-plane echocardiography model. LVEDVecho was used to validate steady-state LVEDA in each experiment. Results. Correlation coefficients for linear and pressure-volume relation analyses ranged from 0.46 to 0.99. The two methods for measuring LVEDV generated compliance curves with an overall reliability coefficient of 0.84. Conclusions. The LVEDVsv/ef method may facilitate real-time determination of LV compliance.

Original languageEnglish
Pages (from-to)76-81
Number of pages6
JournalJournal of Surgical Research
Issue number1
StatePublished - 2002
Externally publishedYes


  • Ejection fraction
  • Left ventricular end-diastolic volume
  • Stroke volume


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