TY - JOUR
T1 - Left ventricular assist devices
T2 - The adolescence of a disruptive technology
AU - Pinney, Sean P.
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Clinical outcomes for patients with advanced heart failure receiving left ventricular assist devices are driven by appropriate patient selection, refined surgical technique, and coordinated medical care. Perhaps even more important is innovative pump design. The introduction and widespread adoption of continuous-flow ventricular assist devices has led to a paradigm shift within the field of mechanical circulatory support, making the promise of lifetime device therapy closer to reality. The disruption caused by this new technology, on the one hand, produced meaningful improvements in patient survival and quality of life, but also introduced new clinical challenges, such as bleeding, pump thrombosis, and acquired valvular heart disease. Further evolution within this field will require financial investment to sustain innovation leading to a fully implantable, durable, and cost-effective pump for a larger segment of patients with advanced heart failure.
AB - Clinical outcomes for patients with advanced heart failure receiving left ventricular assist devices are driven by appropriate patient selection, refined surgical technique, and coordinated medical care. Perhaps even more important is innovative pump design. The introduction and widespread adoption of continuous-flow ventricular assist devices has led to a paradigm shift within the field of mechanical circulatory support, making the promise of lifetime device therapy closer to reality. The disruption caused by this new technology, on the one hand, produced meaningful improvements in patient survival and quality of life, but also introduced new clinical challenges, such as bleeding, pump thrombosis, and acquired valvular heart disease. Further evolution within this field will require financial investment to sustain innovation leading to a fully implantable, durable, and cost-effective pump for a larger segment of patients with advanced heart failure.
KW - Heart failure
KW - innovation
KW - left ventricular assist device
KW - mechanical circulatory support
KW - total artificial heart
UR - http://www.scopus.com/inward/record.url?scp=84942830502&partnerID=8YFLogxK
U2 - 10.1016/j.cardfail.2015.08.005
DO - 10.1016/j.cardfail.2015.08.005
M3 - Review article
C2 - 26318347
AN - SCOPUS:84942830502
SN - 1071-9164
VL - 21
SP - 824
EP - 834
JO - Journal of Cardiac Failure
JF - Journal of Cardiac Failure
IS - 10
ER -