Left ventricular apical thrombus and myocardial viability: A dobutamine stress echocardiographic study

David A. Cusick, Robert O. Bonow, Farooq A. Chaudhry

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The objective of this article was to determine whether the presence of left ventricular apical thrombus is a marker of nonviable myocardium. Reduced coronary blood flow secondary to atherosclerosis may result in chronic reversible left ventricular wall-motion abnormalities. Severe regional abnormalities also predispose to formation of left ventricular thrombus. The relationship between left ventricular apical thrombus and myocardial viability has not been previously described. Eighty patients with coronary artery disease and chronic left ventricular dysfunction were studied by dobutamine stress echocardiography. Left ventricular apical thrombus was identified using echocardiographic criteria. Wall-motion analysis was performed using a standard 16-segment model and ejection fraction was calculated. As a result, 48 patients (60%) had definite or highly suspicious findings for left ventricular thrombus (group 1), and 32 patients (40%) had no thrombus (group 2). Group I had significantly higher composite (54.0 ± 5.8 vs 43.3 ± 6.4) and apical (6.0 ± 2.7 vs 12.4 ± 3.4) wall-motion scores compared to those in group 2 (P = 0.01). Thirty-two patients (67%) in group I demonstrated no contractile reserve in the apical segments, consistent with lack of viability, versus eight patients (25%) in group 2 (P = 0.0003). The number of viable apical segments per patient was significantly less in group 1 (0.7 ± 1.2) versus group 2 (1.8 ± 1.3) (P = 0.01). Left ventricular apical thrombus is more likely to be present when there is absence of myocardial viability in the corresponding segments.

Original languageEnglish
Pages (from-to)547-554
Number of pages8
Issue number6 I
StatePublished - 2000
Externally publishedYes


  • Dobutamine stress echocardiography
  • Myocardial viability
  • Ventricular thrombus


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