Left-handed Z-DNA

DNA molecules are not quiescent, but rather very dynamic and vibrant macromolecules. Alexander Rich discovered left-handed Z-DNA in 1979, but its acceptance by the scientific community has been slow. Z-DNA has been extensively characterized in vitro. Z-DNA exists in biological systems in a dynamic condition, rather than in a static state. Recent developments have helped further characterize its possible roles within eukaryotic cells. The discipline of bio-inorganic chemistry is playing a major role in the examination of the structure and function of Z-DNA. Chemists and molecular biologists are now working very closely together to produce more insights into the chemistry of different nucleic acids. Left-handed DNA is no longer considered to be an in vitro artifact. More members of the scientific community are beginning to speculate on possible roles for this nucleic acid.