Left Atrial Appendage Occlusion in Patients With Atrial Fibrillation and Hemodialysis: An International, Multicentric Registry

Lukas Urbanek, Gunnar H. Heine, Claudia Reddavid, Jacqueline Saw, Iwanari Kawamura, Vivek Y. Reddy, Roberto Galea, Lorenz Räber, Alexander Sedaghat, Domenico G. Della Rocca, Andrea Natale, Gaetano Fassini, Claudio Tondo, Shephal K. Doshi, Dorothy S. Peng, Ralph Stephan von Bardeleben, Felix Kreidel, Boris Schmidt

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The net benefit of oral anticoagulation in patients with end-stage renal disease on hemodialysis (HD) is uncertain. In recent years, left atrial appendage closure (LAAC) has emerged as an alternative to oral anticoagulation; however, there is scant evidence of LAAC in patients on HD. Objectives: This study aimed to assess the feasibility and safety of LAAC in patients on HD. Methods: In an international multicenter registry, patients’ baseline characteristics and procedural and follow-up data were recorded from all patients on HD with atrial fibrillation who underwent LAAC. Results: A total of 147 patients from 9 centers were included. The mean age was 72.6 ± 10.4 years; the mean CHA2DS2-VASc-score was 4.6 ± 1.5, and the mean HAS-BLED-score was 4.7 ± 1.1. Antithrombotic treatment regimens prior to implantation were notably diverse, encompassing more than 12 distinct combinations. Technical successful LAA at first procedure was achieved in 144 of 147 (98%) patients and major complications were observed in 4.7% (7 of 149 procedures). The median follow-up was 427 days (Q1-Q3: 184-797 days), no device-related thrombi were detected, and peridevice leaks ≥5 mm were 1.7% at first imaging control. The most common post-implantation antithrombotic therapy was single antiplatelet therapy with 165.9 patient-years (py). During follow-up of 222.9 py, the annual stroke rate was 0.9%, reflecting an 88% relative risk reduction (P < 0.001) compared to historical data. Similarly, the annual rate of major bleeding was 4.5%, signifying a 55% relative risk reduction (P = 0.023). Throughout follow-up, 29 deaths (19.9%) were recorded. Conclusions: LAAC in end-stage renal disease patients on HD demonstrated an acceptable safety profile, coupled with a notably low incidence of strokes. This was paralleled by low bleeding rates.

Original languageEnglish
Pages (from-to)71-82
Number of pages12
JournalJACC: Clinical Electrophysiology
Volume11
Issue number1
DOIs
StatePublished - Jan 2025

Keywords

  • anticoagulation
  • atrial fibrillation
  • hemodialysis
  • left atrial appendage closure
  • stroke

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