Leberwerterhöhung auf der Intensivstation

Translated title of the contribution: Abnormal liver function tests in the intensive care unit

A. Koch, K. Streetz, J. Tischendorf, C. Trautwein, F. Tacke

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Abnormal liver biochemical and function tests are found in the majority of critically ill patients and are associated with increased mortality. Frequent causes for elevated liver function tests in the intensive care unit (ICU) are acute hepatic dysfunction due to acute hepatitis, acute liver failure (ALF), and drug-induced liver injury (DILI). Furthermore, exacerbations of pre-existing liver diseases (acute on chronic) and secondary liver injury during critical diseases such as sepsis, right heart failure, or cardiogenic shock, resulting in ischemic or hypoxic hepatitis, need to be considered. Elevated liver enzymes may also reflect a complication of ICU treatment measures like drug-related hepatotoxicity, secondary sclerosing cholangitis in critically ill patients (SC-CIP), or related to parenteral nutrition. Comprehensive diagnostic evaluation is essential to identify the underlying etiology of abnormal liver function tests and to initiate the appropriate therapeutic strategies.

Translated title of the contributionAbnormal liver function tests in the intensive care unit
Original languageGerman
Pages (from-to)599-610
Number of pages12
JournalMedizinische Klinik - Intensivmedizin und Notfallmedizin
Volume108
Issue number7
DOIs
StatePublished - Oct 2013
Externally publishedYes

Keywords

  • Drug toxicity
  • Hepatitis
  • Intensive care
  • Liver
  • Sepsis

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