Abstract
A simple and accurate HPLC method for determination of oxcarbazepine (OXC) in a new tablet formulation is described. Chromatographic separation was achieved on a Diamonsil C18 column using a mobile phase consisting of acetonitrile, potassium phosphate monobasic buffer (pH 6.8) and water (36:8:56, v/v) at a flow rate of 1.0 ml/min. Absorbance was monitored at 255 nm where OXC has maximum absorption. The linear range of detection for OXC was from 9.96 to 99.6 μg/ml. The proposed method was validated for selectivity, precision, accuracy and limits of detection and quantitation, etc.
| Original language | English |
|---|---|
| Pages (from-to) | 57-62 |
| Number of pages | 6 |
| Journal | Journal of Pharmaceutical and Biomedical Analysis |
| Volume | 31 |
| Issue number | 1 |
| DOIs | |
| State | Published - 5 Feb 2003 |
| Externally published | Yes |
Keywords
- HPLC
- Oxcarbazepine
- Tablet formulation