Late onset of obesity in male androgen receptor-deficient (AR KO) mice

Takashi Sato, Takahiro Matsumoto, Takashi Yamada, Tomoyuki Watanabe, Hirotaka Kawano, Shigeaki Kato

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167 Scopus citations


An androgen receptor (AR) null mutant mice line was generated by means of a Cre-lox P system. The male (ARL-/Y) (KO) mice exhibited typical features of testicular feminization mutant (Tfm) disease in external reproductive organs with growth retardation. The growth curve of the male AR KO mice was similar to that of the wild-type female littermates until the 10th week of age, but thereafter a drastic increase in the growth was observed with development of obesity. Clear increase in the wet weights of white adipose tissues, but not of brown adipose tissue, was found in the 30-week-old male AR KO mice. However, no significant alteration in serum lipid parameters and food intake was observed. Thus, the present results suggest that AR may serve as a negative regulator of adipose development in adult males.

Original languageEnglish
Pages (from-to)167-171
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number1
StatePublished - 2003
Externally publishedYes


  • AR KO mice
  • Adipocyte
  • Androgen
  • Androgen receptor
  • Lipid accumulation
  • Obesity
  • Tfm disease


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