Late onset of obesity in male androgen receptor-deficient (AR KO) mice

Takashi Sato; Takahiro Matsumoto; Takashi Yamada; Tomoyuki Watanabe; Hirotaka Kawano; Shigeaki Kato

doi:10.1016/S0006-291X(02)02774-2

Late onset of obesity in male androgen receptor-deficient (AR KO) mice

Takashi Sato, Takahiro Matsumoto, Takashi Yamada, Tomoyuki Watanabe, Hirotaka Kawano, Shigeaki Kato

Research output: Contribution to journal › Article › peer-review

171 Scopus citations

Abstract

An androgen receptor (AR) null mutant mice line was generated by means of a Cre-lox P system. The male (AR^L-/Y) (KO) mice exhibited typical features of testicular feminization mutant (Tfm) disease in external reproductive organs with growth retardation. The growth curve of the male AR KO mice was similar to that of the wild-type female littermates until the 10th week of age, but thereafter a drastic increase in the growth was observed with development of obesity. Clear increase in the wet weights of white adipose tissues, but not of brown adipose tissue, was found in the 30-week-old male AR KO mice. However, no significant alteration in serum lipid parameters and food intake was observed. Thus, the present results suggest that AR may serve as a negative regulator of adipose development in adult males.

Original language	English
Pages (from-to)	167-171
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	300
Issue number	1
DOIs	https://doi.org/10.1016/S0006-291X(02)02774-2
State	Published - 2003
Externally published	Yes

Keywords

AR KO mice
Adipocyte
Androgen
Androgen receptor
Lipid accumulation
Obesity
Tfm disease

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10.1016/S0006-291X(02)02774-2

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title = "Late onset of obesity in male androgen receptor-deficient (AR KO) mice",

abstract = "An androgen receptor (AR) null mutant mice line was generated by means of a Cre-lox P system. The male (ARL-/Y) (KO) mice exhibited typical features of testicular feminization mutant (Tfm) disease in external reproductive organs with growth retardation. The growth curve of the male AR KO mice was similar to that of the wild-type female littermates until the 10th week of age, but thereafter a drastic increase in the growth was observed with development of obesity. Clear increase in the wet weights of white adipose tissues, but not of brown adipose tissue, was found in the 30-week-old male AR KO mice. However, no significant alteration in serum lipid parameters and food intake was observed. Thus, the present results suggest that AR may serve as a negative regulator of adipose development in adult males.",

keywords = "AR KO mice, Adipocyte, Androgen, Androgen receptor, Lipid accumulation, Obesity, Tfm disease",

author = "Takashi Sato and Takahiro Matsumoto and Takashi Yamada and Tomoyuki Watanabe and Hirotaka Kawano and Shigeaki Kato",

note = "Funding Information: We thank I. Takada, M. Suzawa, and T. Imai for helpful discussions, R. Nakamura and H. Higuchi for manuscript preparation. This work was supported in part by the Human Frontier Science Program and a grant-in-aid for priority areas from the Ministry of Education, Science, Sports and Culture of Japan (S.K.).",

year = "2003",

doi = "10.1016/S0006-291X(02)02774-2",

language = "English",

volume = "300",

pages = "167--171",

journal = "Biochemical and Biophysical Research Communications",

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T1 - Late onset of obesity in male androgen receptor-deficient (AR KO) mice

AU - Sato, Takashi

AU - Matsumoto, Takahiro

AU - Yamada, Takashi

AU - Watanabe, Tomoyuki

AU - Kawano, Hirotaka

AU - Kato, Shigeaki

N1 - Funding Information: We thank I. Takada, M. Suzawa, and T. Imai for helpful discussions, R. Nakamura and H. Higuchi for manuscript preparation. This work was supported in part by the Human Frontier Science Program and a grant-in-aid for priority areas from the Ministry of Education, Science, Sports and Culture of Japan (S.K.).

PY - 2003

Y1 - 2003

N2 - An androgen receptor (AR) null mutant mice line was generated by means of a Cre-lox P system. The male (ARL-/Y) (KO) mice exhibited typical features of testicular feminization mutant (Tfm) disease in external reproductive organs with growth retardation. The growth curve of the male AR KO mice was similar to that of the wild-type female littermates until the 10th week of age, but thereafter a drastic increase in the growth was observed with development of obesity. Clear increase in the wet weights of white adipose tissues, but not of brown adipose tissue, was found in the 30-week-old male AR KO mice. However, no significant alteration in serum lipid parameters and food intake was observed. Thus, the present results suggest that AR may serve as a negative regulator of adipose development in adult males.

AB - An androgen receptor (AR) null mutant mice line was generated by means of a Cre-lox P system. The male (ARL-/Y) (KO) mice exhibited typical features of testicular feminization mutant (Tfm) disease in external reproductive organs with growth retardation. The growth curve of the male AR KO mice was similar to that of the wild-type female littermates until the 10th week of age, but thereafter a drastic increase in the growth was observed with development of obesity. Clear increase in the wet weights of white adipose tissues, but not of brown adipose tissue, was found in the 30-week-old male AR KO mice. However, no significant alteration in serum lipid parameters and food intake was observed. Thus, the present results suggest that AR may serve as a negative regulator of adipose development in adult males.

KW - AR KO mice

KW - Adipocyte

KW - Androgen

KW - Androgen receptor

KW - Lipid accumulation

KW - Obesity

KW - Tfm disease

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DO - 10.1016/S0006-291X(02)02774-2

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AN - SCOPUS:0037223880

SN - 0006-291X

VL - 300

SP - 167

EP - 171

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 1

ER -

Late onset of obesity in male androgen receptor-deficient (AR KO) mice

Abstract

Keywords

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