Late Bleb-related Endophthalmitis after Trabeculectomy with Adjunctive 5-Fluorouracil

Barbara Wolner; Jeffrey M. Liebmann; Joseph W. Sassani; Robert Ritch; Mark Speaker; Michael Marmor

doi:10.1016/S0161-6420(91)32177-8

Late Bleb-related Endophthalmitis after Trabeculectomy with Adjunctive 5-Fluorouracil

Barbara Wolner, Jeffrey M. Liebmann, Joseph W. Sassani, Robert Ritch, Mark Speaker, Michael Marmor

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285 Scopus citations

Abstract

The incidence of late-onset bleb-related endophthalmitis was evaluated retrospectively in 229 consecutive trabeculectomies performed with adjunctive 5-fluorouracil (5-FU) therapy. Mean follow-up was 23.7 ± 16.3 months (range, 3 to 60 months). Thirteen eyes (5.7%) of 11 patients developed blebrelated endophthalmitis an average of 25.9 ± 17.4 months (range, 5 to 58 months) after surgery. Infection occurred in 9 of 96 (9.4%) procedures performed from below and in 4 of 133 (3.0%) procedures performed superiorly (P = 0.05, Fisher's exact test). The relative risk of bleb-related endophthalmitis in trabeculectomy from below versus above is 4.0 after adjustment for age and sex (95% confidence interval = 1.1, 14.8). Trabeculectomy with adjunctive 5-FU performed from below carries an increased risk of late bleb-related infection. The incidence of late bleb-related endophthalmitis after 5-FU trabeculectomy appears to be higher than that for trabeculectomy without adjunctive 5-FU injections.

Original language	English
Pages (from-to)	1053-1060
Number of pages	8
Journal	Ophthalmology
Volume	98
Issue number	7
DOIs	https://doi.org/10.1016/S0161-6420(91)32177-8
State	Published - 1991
Externally published	Yes

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title = "Late Bleb-related Endophthalmitis after Trabeculectomy with Adjunctive 5-Fluorouracil",

abstract = "The incidence of late-onset bleb-related endophthalmitis was evaluated retrospectively in 229 consecutive trabeculectomies performed with adjunctive 5-fluorouracil (5-FU) therapy. Mean follow-up was 23.7 ± 16.3 months (range, 3 to 60 months). Thirteen eyes (5.7%) of 11 patients developed blebrelated endophthalmitis an average of 25.9 ± 17.4 months (range, 5 to 58 months) after surgery. Infection occurred in 9 of 96 (9.4%) procedures performed from below and in 4 of 133 (3.0%) procedures performed superiorly (P = 0.05, Fisher's exact test). The relative risk of bleb-related endophthalmitis in trabeculectomy from below versus above is 4.0 after adjustment for age and sex (95% confidence interval = 1.1, 14.8). Trabeculectomy with adjunctive 5-FU performed from below carries an increased risk of late bleb-related infection. The incidence of late bleb-related endophthalmitis after 5-FU trabeculectomy appears to be higher than that for trabeculectomy without adjunctive 5-FU injections.",

author = "Barbara Wolner and Liebmann, {Jeffrey M.} and Sassani, {Joseph W.} and Robert Ritch and Mark Speaker and Michael Marmor",

note = "Funding Information: Supported by The Glaucoma Foundation, New York, New York.",

year = "1991",

doi = "10.1016/S0161-6420(91)32177-8",

language = "English",

volume = "98",

pages = "1053--1060",

journal = "Ophthalmology",

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T1 - Late Bleb-related Endophthalmitis after Trabeculectomy with Adjunctive 5-Fluorouracil

AU - Wolner, Barbara

AU - Liebmann, Jeffrey M.

AU - Sassani, Joseph W.

AU - Ritch, Robert

AU - Speaker, Mark

AU - Marmor, Michael

N1 - Funding Information: Supported by The Glaucoma Foundation, New York, New York.

PY - 1991

Y1 - 1991

N2 - The incidence of late-onset bleb-related endophthalmitis was evaluated retrospectively in 229 consecutive trabeculectomies performed with adjunctive 5-fluorouracil (5-FU) therapy. Mean follow-up was 23.7 ± 16.3 months (range, 3 to 60 months). Thirteen eyes (5.7%) of 11 patients developed blebrelated endophthalmitis an average of 25.9 ± 17.4 months (range, 5 to 58 months) after surgery. Infection occurred in 9 of 96 (9.4%) procedures performed from below and in 4 of 133 (3.0%) procedures performed superiorly (P = 0.05, Fisher's exact test). The relative risk of bleb-related endophthalmitis in trabeculectomy from below versus above is 4.0 after adjustment for age and sex (95% confidence interval = 1.1, 14.8). Trabeculectomy with adjunctive 5-FU performed from below carries an increased risk of late bleb-related infection. The incidence of late bleb-related endophthalmitis after 5-FU trabeculectomy appears to be higher than that for trabeculectomy without adjunctive 5-FU injections.

AB - The incidence of late-onset bleb-related endophthalmitis was evaluated retrospectively in 229 consecutive trabeculectomies performed with adjunctive 5-fluorouracil (5-FU) therapy. Mean follow-up was 23.7 ± 16.3 months (range, 3 to 60 months). Thirteen eyes (5.7%) of 11 patients developed blebrelated endophthalmitis an average of 25.9 ± 17.4 months (range, 5 to 58 months) after surgery. Infection occurred in 9 of 96 (9.4%) procedures performed from below and in 4 of 133 (3.0%) procedures performed superiorly (P = 0.05, Fisher's exact test). The relative risk of bleb-related endophthalmitis in trabeculectomy from below versus above is 4.0 after adjustment for age and sex (95% confidence interval = 1.1, 14.8). Trabeculectomy with adjunctive 5-FU performed from below carries an increased risk of late bleb-related infection. The incidence of late bleb-related endophthalmitis after 5-FU trabeculectomy appears to be higher than that for trabeculectomy without adjunctive 5-FU injections.

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DO - 10.1016/S0161-6420(91)32177-8

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SN - 0161-6420

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ER -

Late Bleb-related Endophthalmitis after Trabeculectomy with Adjunctive 5-Fluorouracil

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