Larger putamen size in antipsychotic-naïve individuals with schizotypal personality disorder

Eran Chemerinski, William Byne, Jeanine C. Kolaitis, Cathryn F. Glanton, Emily L. Canfield, Randall E. Newmark, M. Mehmet Haznedar, Vladan Novakovic, King Wai Chu, Larry J. Siever, Erin A. Hazlett

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Objective: To (a) compare the size of the dorsal and ventral striatum (caudate and putamen) in a large sample of antipsychotic-naïve individuals with schizotypal personality disorder (SPD) and healthy control participants; (b) examine symptom correlates of striatal size in SPD. Methods: The left and right caudate and putamen were hand-traced on structural MRI at five dorsal to ventral slice levels in 76 SPD and 148 healthy control participants. A Group × Region (caudate, putamen) × Slice (1-5: ventral, 2, 3, 4, dorsal) × Hemisphere (left, right) mixed-model MANOVA was conducted on size relative to whole brain. Results: Primary results showed that compared with the controls, the SPD group showed (a) larger bilateral putamen size overall and this enlargement was more pronounced at the most ventral and dorsal levels; in contrast, there were no between-group differences in caudate volume; (b) larger bilateral size of the striatum ventrally, averaged across the caudate and putamen. Among the SPD group, larger striatal size ventrally, particularly in the left hemisphere was associated with less severe paranoid symptoms. Conclusions: Striatal size is abnormal in SPD and resembles that of patients with schizophrenia who respond well to antipsychotic treatment. The results suggest that striatal size may be an important endophenotype to consider when developing new pharmacological treatments and when studying factors mitigating psychosis.

Original languageEnglish
Pages (from-to)158-164
Number of pages7
JournalSchizophrenia Research
Issue number1
StatePublished - Jan 2013


  • Caudate
  • MRI
  • Putamen
  • Schizophrenia
  • Schizotypal personality disorder
  • Striatal size
  • Striatum


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