TY - JOUR
T1 - Larger brains in medication naive high-functioning subjects with pervasive developmental disorder
AU - Palmen, Saskia J.M.C.
AU - Hulshoff Pol, Hilleke E.
AU - Kemner, Chantal
AU - Schnack, Hugo G.
AU - Janssen, Joost
AU - Kahn, René S.
AU - Van Engeland, Herman
N1 - Funding Information:
The work was financially supported by the Korczak foundation. This work was presented in part at the second international meeting for autism research (IMFAR) in Orlando, US, 1-2 November 2002.
PY - 2004/12
Y1 - 2004/12
N2 - Background: Are brain volumes of individuals with Pervasive Developmental Disorder (PDD) still enlarged in adolescence and adulthood, and if so, is this enlargement confined to the gray and/or the white matter and is it global or more prominent in specific brain regions. Methods: Brain MRI scans were made of 21 adolescents with PDD and 21 closely matched controls. Results: All brain volumes, except the white matter, were significantly larger in patients. After correction for brain volume, ventricular volumes remained significantly larger in patients. Conclusions: Patients showed a proportional, global increase in gray matter and cerebellum volume, and a disproportional increase in ventricular volumes. Thus, at least in high-functioning patients with PDD, brain enlargement may still be present in adult life.
AB - Background: Are brain volumes of individuals with Pervasive Developmental Disorder (PDD) still enlarged in adolescence and adulthood, and if so, is this enlargement confined to the gray and/or the white matter and is it global or more prominent in specific brain regions. Methods: Brain MRI scans were made of 21 adolescents with PDD and 21 closely matched controls. Results: All brain volumes, except the white matter, were significantly larger in patients. After correction for brain volume, ventricular volumes remained significantly larger in patients. Conclusions: Patients showed a proportional, global increase in gray matter and cerebellum volume, and a disproportional increase in ventricular volumes. Thus, at least in high-functioning patients with PDD, brain enlargement may still be present in adult life.
KW - Brain MRI
KW - autism
KW - cortical lobes
KW - gray matter
KW - white matter
UR - http://www.scopus.com/inward/record.url?scp=11144252798&partnerID=8YFLogxK
U2 - 10.1007/s10803-004-5282-2
DO - 10.1007/s10803-004-5282-2
M3 - Article
C2 - 15679181
AN - SCOPUS:11144252798
SN - 0162-3257
VL - 34
SP - 603
EP - 613
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
IS - 6
ER -