TY - JOUR
T1 - Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits
AU - On behalf of the DIAMANTE Hispanic/Latino Consortium
AU - Global Hispanic Lipids Consortium
AU - Petty, Lauren E.
AU - Chen, Hung Hsin
AU - Frankel, Elizabeth G.
AU - Zhu, Wanying
AU - Downie, Carolina G.
AU - Graff, Mariaelisa
AU - Lin, Phillip
AU - Sharma, Priya
AU - Zhang, Xinruo
AU - Scartozzi, Alyssa C.
AU - Roshani, Rashedeh
AU - Landman, Joshua M.
AU - Boehnke, Michael
AU - Bowden, Donald W.
AU - Chambers, John C.
AU - Mahajan, Anubha
AU - McCarthy, Mark I.
AU - Ng, Maggie C.Y.
AU - Sim, Xueling
AU - Spracklen, Cassandra N.
AU - Zhang, Weihua
AU - Preuss, Michael
AU - Bottinger, Erwin P.
AU - Nadkarni, Girish N.
AU - Loos, Ruth J.F.
AU - Chen, Yii Der Ida
AU - Tan, Jingyi
AU - Ipp, Eli
AU - Genter, Pauline
AU - Emery, Leslie S.
AU - Louie, Tin
AU - Sofer, Tamar
AU - Stilp, Adrienne M.
AU - Taylor, Kent D.
AU - Xiang, Anny H.
AU - Buchanan, Thomas A.
AU - Roll, Kathryn
AU - Gao, Chuan
AU - Palmer, Nicholette D.
AU - Norris, Jill M.
AU - Wagenknecht, Lynne E.
AU - Nousome, Darryl
AU - Varma, Rohit
AU - McKean-Cowdin, Roberta
AU - Guo, Xiuqing
AU - Hai, Yang
AU - Hsueh, Willa
AU - Sandow, Kevin
AU - Parra, Esteban J.
AU - Fried, Susan K.
N1 - Publisher Copyright:
© The Author(s) 2025.
PY - 2025/12
Y1 - 2025/12
N2 - Here, we present a multi-omics study of type 2 diabetes and quantitative blood lipid and lipoprotein traits conducted to date in Hispanic/Latino populations (nmax = 63,184). We conduct a meta-analysis of 16 type 2 diabetes and 19 lipid trait GWAS, identifying 20 genome-wide significant loci for type 2 diabetes, including one novel locus and novel signals at two known loci, based on fine-mapping. We also identify sixty-one genome-wide significant loci across the lipid/lipoprotein traits, including nine novel loci, and novel signals at 19 known loci through fine-mapping. Next, we analyze genetically regulated expression, perform Mendelian randomization, and analyze association with transcriptomic and proteomic measure using multi-omics data from a Hispanic/Latino population. Using this approach, we identify genes linked to type 2 diabetes and lipid/lipoprotein traits, including TMEM205 and NEDD9 for HDL cholesterol, TREH for triglycerides, and ANXA4 for type 2 diabetes.
AB - Here, we present a multi-omics study of type 2 diabetes and quantitative blood lipid and lipoprotein traits conducted to date in Hispanic/Latino populations (nmax = 63,184). We conduct a meta-analysis of 16 type 2 diabetes and 19 lipid trait GWAS, identifying 20 genome-wide significant loci for type 2 diabetes, including one novel locus and novel signals at two known loci, based on fine-mapping. We also identify sixty-one genome-wide significant loci across the lipid/lipoprotein traits, including nine novel loci, and novel signals at 19 known loci through fine-mapping. Next, we analyze genetically regulated expression, perform Mendelian randomization, and analyze association with transcriptomic and proteomic measure using multi-omics data from a Hispanic/Latino population. Using this approach, we identify genes linked to type 2 diabetes and lipid/lipoprotein traits, including TMEM205 and NEDD9 for HDL cholesterol, TREH for triglycerides, and ANXA4 for type 2 diabetes.
UR - https://www.scopus.com/pages/publications/105003323438
U2 - 10.1038/s41467-025-58574-z
DO - 10.1038/s41467-025-58574-z
M3 - Article
C2 - 40210677
AN - SCOPUS:105003323438
SN - 2041-1723
VL - 16
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 3438
ER -