@article{dd4e715fd25e428ba1fc1d858085bf07,
title = "Large-scale cellular-resolution gene profiling in human neocortex reveals species-specific molecular signatures",
abstract = "Although there have been major advances in elucidating the functional biology of the human brain, relatively little is known of its cellular and molecular organization. Here we report a large-scale characterization of the expression of ∼1,000 genes important for neural functions by in situ hybridization at a cellular resolution in visual and temporal cortices of adult human brains. These data reveal diverse gene expression patterns and remarkable conservation of each individual gene's expression among individuals (95%), cortical areas (84%), and between human and mouse (79%). A small but substantial number of genes (21%) exhibited species-differential expression. Distinct molecular signatures, comprised of genes both common between species and unique to each, were identified for each major cortical cell type. The data suggest that gene expression profile changes may contribute to differential cortical function across species, and in particular, a shift from corticosubcortical to more predominant corticocortical communications in the human brain.",
author = "Hongkui Zeng and Shen, {Elaine H.} and Hohmann, {John G.} and Oh, {Seung Wook} and Amy Bernard and Royall, {Joshua J.} and Glattfelder, {Katie J.} and Sunkin, {Susan M.} and Morris, {John A.} and Guillozet-Bongaarts, {Angela L.} and Smith, {Kimberly A.} and Ebbert, {Amanda J.} and Beryl Swanson and Leonard Kuan and Page, {Damon T.} and Overly, {Caroline C.} and Lein, {Ed S.} and Hawrylycz, {Michael J.} and Hof, {Patrick R.} and Hyde, {Thomas M.} and Kleinman, {Joel E.} and Jones, {Allan R.}",
note = "Funding Information: We are grateful for the technical support and expertise of the Atlas Production Team, led by Paul Wohnoutka, and the Information Technology Team, led by Chinh Dang, at the Allen Institute, without which the work would have not been accomplished. We thank Drs. Deborah Mash and Margaret Basile of the University of Miami Brain Endowment Bank for providing tissue. This work was funded by the Allen Institute for Brain Science. The authors wish to thank the Allen Institute founders, Paul G. Allen and Jody Allen, for their vision, encouragement, and support. ",
year = "2012",
month = apr,
day = "13",
doi = "10.1016/j.cell.2012.02.052",
language = "English",
volume = "149",
pages = "483--496",
journal = "Cell",
issn = "0092-8674",
publisher = "Elsevier B.V.",
number = "2",
}