Large-scale brain dynamics in disorders of consciousness

Nicholas D. Schiff, Tanya Nauvel, Jonathan D. Victor

Research output: Contribution to journalReview articlepeer-review

97 Scopus citations

Abstract

Brain injury profoundly affects global brain dynamics, and these changes are manifest in the electroencephalogram (EEG). Despite the heterogeneity of injury mechanisms and the modularity of brain function, there is a commonality of dynamical features that characterize the EEG along the gamut from coma to recovery. After severest injury, EEG activity is concentrated below 1. Hz. In minimally conscious state during wakefulness, there is a peak of activity in the 3-7. Hz range, often coherent across the brain, and often also activity in the beta (15-30. Hz) range. These spectral changes likely result from varying degrees of functional deafferentation at thalamic and cortical levels. EEG-based indices of brain dynamics that go beyond these simple spectral measures may provide further diagnostic information and physiologic insights.

Original languageEnglish
Pages (from-to)7-14
Number of pages8
JournalCurrent Opinion in Neurobiology
Volume25
DOIs
StatePublished - Apr 2014
Externally publishedYes

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