Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors

Christel Rousseaux, Xavier Thuru, Agathe Gelot, Nicolas Barnich, Christel Neut, Laurent Dubuquoy, Caroline Dubuquoy, Emilie Merour, Karen Geboes, Mathias Chamaillard, Arthur Ouwehand, Greg Leyer, Didier Carcano, Jean Frédéric Colombel, Denis Ardid, Pierre Desreumaux

Research output: Contribution to journalArticlepeer-review

662 Scopus citations


Abdominal pain is common in the general population and, in patients with irritable bowel syndrome, is attributed to visceral hypersensitivity. We found that oral administration of specific Lactobacillus strains induced the expression of μ-opioid and cannabinoid receptors in intestinal epithelial cells, and mediated analgesic functions in the gut - similar to the effects of morphine. These results suggest that the microbiology of the intestinal tract influences our visceral perception, and suggest new approaches for the treament of abdominal pain and irritable bowel syndrome.

Original languageEnglish
Pages (from-to)35-37
Number of pages3
JournalNature Medicine
Issue number1
StatePublished - Jan 2007
Externally publishedYes


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