Lack of prolactin response to insulin-induced hypoglycemia in growth hormone-deficient and non growth hormone-deficient children

Robert Rapaport, Norman H. Ertel

Research output: Contribution to journalArticlepeer-review

Abstract

We have studied the responses of serum prolactin to insulin-induced hypoglycemia in 6 children with isolated growth hormone deficiency and 8 non growth hormone-deficient children. The growth hormone-deficient children showed a decrease in serum glucose level from a baseline of 79.7 ± 5.3 mg/dl (mean ± SEM) to a nadir of 24.0 ± 2.4 mg/dl (p <.0001. Their peak serum prolactin level of 17.7 ± 3.8 ng/ml was not significantly different from the baseline value of 9.5 ± 1.9 ng/ml (N.S.). The non growth hormone-deficient children showed a decrease in serum glucose level from a baseline of 80.0 ± 4.3 mg/dl to a nadir of 30.1 ± 2.0 mg/dl (p <.0001). Their peak serum prolactin level of 7.4 ± 1.4 ng/ml was likewise not significantly different from the baseline of 5.8 ± 0.9 ng/ml (N.S.). Both growth hormone-deficient and non growth hormone-deficient children had significant and similar prolactin responses to TRH, reaching normal mean peak values of 27.6 ± 3.8 ng/ml (p <.005 vs. baseline) and 24.5 ± 3.0 ng/ml (p <.005 vs. baseline), respectively. We conclude that the prolactin response to insulin-induced hypoglycemia is not a useful test for the assessment of hypothalamic-pituitary function in children.

Original languageEnglish
Pages (from-to)109-116
Number of pages8
JournalJournal of Pediatric Endocrinology and Metabolism
Volume3
Issue number2
DOIs
StatePublished - Apr 1989
Externally publishedYes

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