Lack of correlation between prostate-specific antigen density and prostatic shrinkage in response to finasteride therapy

A. Kirschenbaum, E. Pacheco, B. J. Schuval, A. C. Levine

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

We attempted to correlate prostate volume reduction in response to finasteride treatment with initial prostate-specific antigen (PSA) levels and PSA density in men with symptomatic benign prostatic hyperplasia (BPH). The average reductions in prostatic volume (transrectal ultrasonography) were 27% and 34% after 6 and 12 months of finasteride therapy, respectively. Serum PSA levels decreased by 45% (6 months) and 50% (12 months). There was a positive correlation between initial serum PSA values and initial prostate volumes (r = 0.57, P < 0.001). There was no correlation, however, between the initial serum PSA or PSA-density values and prostate volume reduction. These data indicate that initial serum PSA and PSA-density values are not predictive of the response to finasteride therapy in terms of prostate size reduction.

Original languageEnglish
Pages (from-to)360-362
Number of pages3
JournalWorld Journal of Urology
Volume14
Issue number6
DOIs
StatePublished - 1996

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