Labelling of fluorinated aromatics by isotopic exchange with [18F]fluoride

Fulvio Cacace, Maurizio Speranza, Alfred P. Wolf, Joanna S. Fowler

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


The efficient and rapid nucleophilic exchange of fluorine by fluoride‐18F ion in aromatic rings is reported here utilizing rubidium‐18F‐fluoride in DMSO on model compounds. Specific activities in the 3 × 104 Ci/mol region are readily achievable. Nucleophilic substitution is shown to be an attractive modality for fluorine‐18 labeling of aromatic compounds.

Original languageEnglish
Pages (from-to)1721-1730
Number of pages10
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Issue number12
StatePublished - Dec 1981
Externally publishedYes


  • fluorine‐18
  • nucleophilic aromatic substitution
  • radiopharmaceuticals


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