A convenient method for the synthesis of 18F‐2‐deoxy‐2‐fluoro‐D‐glucose (4) and 18F‐2‐deoxy‐2‐fluoro‐D‐mannose (8) by the direct fluorination of 3,4,6‐tri‐0‐acetyl‐D‐glucal with 18F‐F2 is described. 14C‐2‐deoxy‐2‐fluoro‐D‐glucose has been synthesized from 14C‐3,4,6‐tri‐0‐acetyl‐D‐glucal (from D‐[14c(U)]‐glucose) by fluorination with F2 (Method 1) and CF3OF (Method 2). These labeled analogs of 2‐deoxy‐D‐glucose were required for the study of local cerebral glucose metabolism.
|Number of pages||9|
|Journal||Journal of Labelled Compounds and Radiopharmaceuticals|
|State||Published - 1978|