Labeled 2‐deoxy‐D‐glucose analogs. 18F‐labeled 2‐deoxy‐2‐fluoro‐D‐glucose, 2‐deoxy‐2‐fluoro‐D‐mannose and 14C‐2‐deoxy‐2‐fluoro‐D‐glucose

T. Ido; C. ‐N Wan; V. Casella; J. S. Fowler; A. P. Wolf; M. Reivich; D. E. Kuhl

doi:10.1002/jlcr.2580140204

Labeled 2‐deoxy‐D‐glucose analogs. ¹⁸F‐labeled 2‐deoxy‐2‐fluoro‐D‐glucose, 2‐deoxy‐2‐fluoro‐D‐mannose and ¹⁴C‐2‐deoxy‐2‐fluoro‐D‐glucose

T. Ido, C. ‐N Wan, V. Casella, J. S. Fowler, A. P. Wolf, M. Reivich, D. E. Kuhl

Research output: Contribution to journal › Article › peer-review

356 Scopus citations

Abstract

A convenient method for the synthesis of ¹⁸F‐2‐deoxy‐2‐fluoro‐D‐glucose (4) and ¹⁸F‐2‐deoxy‐2‐fluoro‐D‐mannose (8) by the direct fluorination of 3,4,6‐tri‐0‐acetyl‐D‐glucal with ¹⁸F‐F₂ is described. ¹⁴C‐2‐deoxy‐2‐fluoro‐D‐glucose has been synthesized from ¹⁴C‐3,4,6‐tri‐0‐acetyl‐D‐glucal (from D‐[¹⁴c(U)]‐glucose) by fluorination with F₂ (Method 1) and CF₃OF (Method 2). These labeled analogs of 2‐deoxy‐D‐glucose were required for the study of local cerebral glucose metabolism.

Original language	English
Pages (from-to)	175-183
Number of pages	9
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	14
Issue number	2
DOIs	https://doi.org/10.1002/jlcr.2580140204
State	Published - 1978
Externally published	Yes

Keywords

C‐2‐deoxy‐2‐fluoro‐D‐glucose
F‐2‐deoxy‐2‐fluoro‐D‐glucose
F‐2‐deoxy‐2‐fluoro‐D‐mannose

Access to Document

10.1002/jlcr.2580140204

Cite this

Ido, T., Wan, C. N., Casella, V., Fowler, J. S., Wolf, A. P., Reivich, M., & Kuhl, D. E. (1978). Labeled 2‐deoxy‐D‐glucose analogs. ¹⁸F‐labeled 2‐deoxy‐2‐fluoro‐D‐glucose, 2‐deoxy‐2‐fluoro‐D‐mannose and ¹⁴C‐2‐deoxy‐2‐fluoro‐D‐glucose. Journal of Labelled Compounds and Radiopharmaceuticals, 14(2), 175-183. https://doi.org/10.1002/jlcr.2580140204

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title = "Labeled 2‐deoxy‐D‐glucose analogs. 18F‐labeled 2‐deoxy‐2‐fluoro‐D‐glucose, 2‐deoxy‐2‐fluoro‐D‐mannose and 14C‐2‐deoxy‐2‐fluoro‐D‐glucose",

abstract = "A convenient method for the synthesis of 18F‐2‐deoxy‐2‐fluoro‐D‐glucose (4) and 18F‐2‐deoxy‐2‐fluoro‐D‐mannose (8) by the direct fluorination of 3,4,6‐tri‐0‐acetyl‐D‐glucal with 18F‐F2 is described. 14C‐2‐deoxy‐2‐fluoro‐D‐glucose has been synthesized from 14C‐3,4,6‐tri‐0‐acetyl‐D‐glucal (from D‐[14c(U)]‐glucose) by fluorination with F2 (Method 1) and CF3OF (Method 2). These labeled analogs of 2‐deoxy‐D‐glucose were required for the study of local cerebral glucose metabolism.",

keywords = "C‐2‐deoxy‐2‐fluoro‐D‐glucose, F‐2‐deoxy‐2‐fluoro‐D‐glucose, F‐2‐deoxy‐2‐fluoro‐D‐mannose",

author = "T. Ido and Wan, {C. ‐N} and V. Casella and Fowler, {J. S.} and Wolf, {A. P.} and M. Reivich and Kuhl, {D. E.}",

year = "1978",

doi = "10.1002/jlcr.2580140204",

language = "English",

volume = "14",

pages = "175--183",

journal = "Journal of Labelled Compounds and Radiopharmaceuticals",

issn = "0362-4803",

publisher = "John Wiley and Sons Ltd",

number = "2",

}

Ido, T, Wan, CN, Casella, V, Fowler, JS, Wolf, AP, Reivich, M & Kuhl, DE 1978, 'Labeled 2‐deoxy‐D‐glucose analogs. ¹⁸F‐labeled 2‐deoxy‐2‐fluoro‐D‐glucose, 2‐deoxy‐2‐fluoro‐D‐mannose and ¹⁴C‐2‐deoxy‐2‐fluoro‐D‐glucose', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 14, no. 2, pp. 175-183. https://doi.org/10.1002/jlcr.2580140204

Labeled 2‐deoxy‐D‐glucose analogs. ¹⁸F‐labeled 2‐deoxy‐2‐fluoro‐D‐glucose, 2‐deoxy‐2‐fluoro‐D‐mannose and ¹⁴C‐2‐deoxy‐2‐fluoro‐D‐glucose. / Ido, T.; Wan, C. ‐N; Casella, V. et al.
In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 14, No. 2, 1978, p. 175-183.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Labeled 2‐deoxy‐D‐glucose analogs. 18F‐labeled 2‐deoxy‐2‐fluoro‐D‐glucose, 2‐deoxy‐2‐fluoro‐D‐mannose and 14C‐2‐deoxy‐2‐fluoro‐D‐glucose

AU - Ido, T.

AU - Wan, C. ‐N

AU - Casella, V.

AU - Fowler, J. S.

AU - Wolf, A. P.

AU - Reivich, M.

AU - Kuhl, D. E.

PY - 1978

Y1 - 1978

N2 - A convenient method for the synthesis of 18F‐2‐deoxy‐2‐fluoro‐D‐glucose (4) and 18F‐2‐deoxy‐2‐fluoro‐D‐mannose (8) by the direct fluorination of 3,4,6‐tri‐0‐acetyl‐D‐glucal with 18F‐F2 is described. 14C‐2‐deoxy‐2‐fluoro‐D‐glucose has been synthesized from 14C‐3,4,6‐tri‐0‐acetyl‐D‐glucal (from D‐[14c(U)]‐glucose) by fluorination with F2 (Method 1) and CF3OF (Method 2). These labeled analogs of 2‐deoxy‐D‐glucose were required for the study of local cerebral glucose metabolism.

AB - A convenient method for the synthesis of 18F‐2‐deoxy‐2‐fluoro‐D‐glucose (4) and 18F‐2‐deoxy‐2‐fluoro‐D‐mannose (8) by the direct fluorination of 3,4,6‐tri‐0‐acetyl‐D‐glucal with 18F‐F2 is described. 14C‐2‐deoxy‐2‐fluoro‐D‐glucose has been synthesized from 14C‐3,4,6‐tri‐0‐acetyl‐D‐glucal (from D‐[14c(U)]‐glucose) by fluorination with F2 (Method 1) and CF3OF (Method 2). These labeled analogs of 2‐deoxy‐D‐glucose were required for the study of local cerebral glucose metabolism.

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