LAB: A new membrane-associated adaptor molecule in B cell activation

Erin Janssen, Minghua Zhu, Weijia Zhang, Surapong Koonpaew, Weiguo Zhang

Research output: Contribution to journalArticlepeer-review

138 Scopus citations

Abstract

The adaptor molecule, linker for activation of T cells (LAT), is essential in T cell activation and development; a similar molecule in B cells has not yet been identified. Here, we report the identification of a new adaptor protein, linker for activation of B cells (LAB). Like LAT, LAB was localized to lipid rafts. Upon activation via the B cell receptor (BCR), LAB was phosphorylated and interacted with the adaptor protein Grb2. Decreased LAB expression led to a reduction in BCR-mediated calcium flux and Erk activation. LAB rescued thymocyte development but not normal T cell activation in LAT-/- mice. Our data suggest that LAB links BCR engagement to downstream signaling pathways.

Original languageEnglish
Pages (from-to)117-123
Number of pages7
JournalNature Immunology
Volume4
Issue number2
DOIs
StatePublished - 1 Feb 2003
Externally publishedYes

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