Thrombin plays a pivotal role in the pathogenesis of arterial thrombosis. Platelet-rich thrombosis after arterial injury is dependent on the depth and extent of injury, local rheological conditions and the persistence of residual mural thrombus. The unique effects of specific thrombin inhibitors, including thrombin action on platelets and blood coagulation demonstrated in experimental and preliminary clinical trials, suggest that specific thrombin inhibitors may be the next major advance in antithrombotic therapy of acute coronary syndromes.
|Translated title of the contribution||Thrombin and thrombin inhibitors in arterial thrombosis|
|Number of pages||8|
|Journal||Sang Thrombose Vaisseaux|
|State||Published - 1994|