L-dopa induced plasma glucagon release

D. T. George, E. J. Rayfield

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


L-dopa was found to induce the release of pancreatic glucagon as well as growth hormone in rhesus monkeys. This release of glucagon was unaffected by either α - or β-adrenergic blockade and may be the result of direct dopaminergic stimulation of the pancreas. The resultant hyperglycemia may be important in explaining the clinical observation of worsening of diabetic control in parkinsonian diabetic patients on L-dopa therapy.

Original languageEnglish
Pages (from-to)618-621
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Issue number3
StatePublished - Sep 1974
Externally publishedYes


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