L-α-glycerylphosphorylcholine enhances the amplitude of the pattern electroretinogram in rhesus monkeys. A pilot study

A. Antal; S. Z. Keri; I. Bodis-Wollner

L-α-glycerylphosphorylcholine enhances the amplitude of the pattern electroretinogram in rhesus monkeys. A pilot study

A. Antal
, S. Z. Keri
, I. Bodis-Wollner

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The effects of L-α-glyceryl-phosphorylcholine (LGPC), a putative acetylcholine precursor, were studied on the pattern electroretinogram (PERG) in two rhesus monkeys. In the time interval 10-30 min after LGPC administration (85 mg/kg im.), the amplitude of the PERG increased significantly. In both monkeys the amplitude enhancement was more pronounced for low spatial frequency stimuli (1 cycle/degree) than for medium spatial frequency gratings (5 cycles/degree). This result suggests that besides the general facilitatory properties, LGPC may have specific spatial frequency tuning effects at the level of retinal information processing.

Original language	English
Pages (from-to)	407-412
Number of pages	6
Journal	Neurobiology
Volume	7
Issue number	4
State	Published - 1999
Externally published	Yes

Keywords

L-α-glycerylphosphorylcholine (LGPC)
Monkey
Pattern electroretinogram (PERG)
Spatial frequency

Cite this

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title = "L-α-glycerylphosphorylcholine enhances the amplitude of the pattern electroretinogram in rhesus monkeys. A pilot study",

abstract = "The effects of L-α-glyceryl-phosphorylcholine (LGPC), a putative acetylcholine precursor, were studied on the pattern electroretinogram (PERG) in two rhesus monkeys. In the time interval 10-30 min after LGPC administration (85 mg/kg im.), the amplitude of the PERG increased significantly. In both monkeys the amplitude enhancement was more pronounced for low spatial frequency stimuli (1 cycle/degree) than for medium spatial frequency gratings (5 cycles/degree). This result suggests that besides the general facilitatory properties, LGPC may have specific spatial frequency tuning effects at the level of retinal information processing.",

keywords = "L-α-glycerylphosphorylcholine (LGPC), Monkey, Pattern electroretinogram (PERG), Spatial frequency",

author = "A. Antal and Keri, \{S. Z.\} and I. Bodis-Wollner",

year = "1999",

language = "English",

volume = "7",

pages = "407--412",

journal = "Neurobiology",

issn = "1216-8068",

publisher = "Ifjusagi Lap-es Konyvkiado Vallalat",

number = "4",

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T1 - L-α-glycerylphosphorylcholine enhances the amplitude of the pattern electroretinogram in rhesus monkeys. A pilot study

AU - Antal, A.

AU - Keri, S. Z.

AU - Bodis-Wollner, I.

PY - 1999

Y1 - 1999

N2 - The effects of L-α-glyceryl-phosphorylcholine (LGPC), a putative acetylcholine precursor, were studied on the pattern electroretinogram (PERG) in two rhesus monkeys. In the time interval 10-30 min after LGPC administration (85 mg/kg im.), the amplitude of the PERG increased significantly. In both monkeys the amplitude enhancement was more pronounced for low spatial frequency stimuli (1 cycle/degree) than for medium spatial frequency gratings (5 cycles/degree). This result suggests that besides the general facilitatory properties, LGPC may have specific spatial frequency tuning effects at the level of retinal information processing.

AB - The effects of L-α-glyceryl-phosphorylcholine (LGPC), a putative acetylcholine precursor, were studied on the pattern electroretinogram (PERG) in two rhesus monkeys. In the time interval 10-30 min after LGPC administration (85 mg/kg im.), the amplitude of the PERG increased significantly. In both monkeys the amplitude enhancement was more pronounced for low spatial frequency stimuli (1 cycle/degree) than for medium spatial frequency gratings (5 cycles/degree). This result suggests that besides the general facilitatory properties, LGPC may have specific spatial frequency tuning effects at the level of retinal information processing.

KW - L-α-glycerylphosphorylcholine (LGPC)

KW - Monkey

KW - Pattern electroretinogram (PERG)

KW - Spatial frequency

UR - https://www.scopus.com/pages/publications/0033364478

M3 - Article

C2 - 10897800

AN - SCOPUS:0033364478

SN - 1216-8068

VL - 7

SP - 407

EP - 412

JO - Neurobiology

JF - Neurobiology

IS - 4

ER -

L-α-glycerylphosphorylcholine enhances the amplitude of the pattern electroretinogram in rhesus monkeys. A pilot study

Abstract

Keywords

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