TY - CHAP
T1 - Krüppel-like factors KLF6 and KLF6-SV1 in the diagnosis and treatment of cancer
AU - Difeo, Analisa
AU - Narla, Goutham
AU - Martignetti, John A.
PY - 2009
Y1 - 2009
N2 - Beyond their initial identification in prostate cancer, the tumor suppressor KLF6 and its alternatively spliced oncogenic isoform KLF6-SV1 have now been associated with a number of human cancers. Expression patterns of each have been linked to tumor stage, disease recurrence, chemotherapy response and overall survival. Most recently, inhibition of KLF6-SV1 has been shown to increase survival in a pre-clinical model of ovarian cancer. This chapter reviews the basic biology of KLF6 and KLF6-SV1 as it relates to cancer, summarizes the published studies to date, and highlights the scientific rationale for therapeutically targeting KLF6 and KLF6-SV1 as a novel treatment paradigm.
AB - Beyond their initial identification in prostate cancer, the tumor suppressor KLF6 and its alternatively spliced oncogenic isoform KLF6-SV1 have now been associated with a number of human cancers. Expression patterns of each have been linked to tumor stage, disease recurrence, chemotherapy response and overall survival. Most recently, inhibition of KLF6-SV1 has been shown to increase survival in a pre-clinical model of ovarian cancer. This chapter reviews the basic biology of KLF6 and KLF6-SV1 as it relates to cancer, summarizes the published studies to date, and highlights the scientific rationale for therapeutically targeting KLF6 and KLF6-SV1 as a novel treatment paradigm.
UR - http://www.scopus.com/inward/record.url?scp=84900108715&partnerID=8YFLogxK
U2 - 10.1007/978-4-431-87775-2_17
DO - 10.1007/978-4-431-87775-2_17
M3 - Chapter
AN - SCOPUS:84900108715
SN - 9784431877745
SP - 223
EP - 244
BT - The Biology of Krüppel-like Factors
PB - Springer Japan
ER -