Krüppel-like factors KLF6 and KLF6-SV1 in the diagnosis and treatment of cancer

Analisa Difeo, Goutham Narla, John A. Martignetti

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Beyond their initial identification in prostate cancer, the tumor suppressor KLF6 and its alternatively spliced oncogenic isoform KLF6-SV1 have now been associated with a number of human cancers. Expression patterns of each have been linked to tumor stage, disease recurrence, chemotherapy response and overall survival. Most recently, inhibition of KLF6-SV1 has been shown to increase survival in a pre-clinical model of ovarian cancer. This chapter reviews the basic biology of KLF6 and KLF6-SV1 as it relates to cancer, summarizes the published studies to date, and highlights the scientific rationale for therapeutically targeting KLF6 and KLF6-SV1 as a novel treatment paradigm.

Original languageEnglish
Title of host publicationThe Biology of Krüppel-like Factors
PublisherSpringer Japan
Number of pages22
ISBN (Print)9784431877745
StatePublished - 2009


Dive into the research topics of 'Krüppel-like factors KLF6 and KLF6-SV1 in the diagnosis and treatment of cancer'. Together they form a unique fingerprint.

Cite this