Krüppel-like factors in mammalian stem cells and development

Agnieszka B. Bialkowska, Vincent W. Yang, Sandeep K. Mallipattu

Research output: Contribution to journalArticlepeer-review

90 Scopus citations

Abstract

Krüppel-like factors (KLFs) are a family of zinc-finger transcription factors that are found in many species. Recent studies have shown that KLFs play a fundamental role in regulating diverse biological processes such as cell proliferation, differentiation, development and regeneration. Of note, several KLFs are also crucial for maintaining pluripotency and, hence, have been linked to reprogramming and regenerative medicine approaches. Here, we review the crucial functions of KLFs in mammalian embryogenesis, stem cell biology and regeneration, as revealed by studies of animal models. We also highlight how KLFs have been implicated in human diseases and outline potential avenues for future research.

Original languageEnglish
Pages (from-to)737-754
Number of pages18
JournalDevelopment (Cambridge)
Volume144
Issue number5
DOIs
StatePublished - 1 Mar 2017
Externally publishedYes

Keywords

  • Cellular regeneration
  • Human disease
  • Krüppel-like factors
  • Mammalian development
  • Stem cells

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