Kounis Syndrome: A Review of an Uncommon Cause of Acute Coronary Syndrome

Steven Douedi, Mihir Odak, Anton Mararenko, Jacqueline Ross, Brett Sealove

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Kounis syndrome is a hypersensitivity disorder secondary to allergy or anaphylaxis that can result in acute coronary syndrome. Kounis syndrome has an increasing prevalence since its first identification in 1950. Divided into 3 subtypes, each with diagnostic criteria, the management of Kounis syndrome presents a clinical challenge. We aim to identify the pathophysiological mechanisms and review the diagnosis, epidemiology, management strategies, and future directions of Kounis syndrome. As Kounis syndrome becomes more widely recognized in the medical community, the role of diagnosis, treatment, and future immunomodulatory prevention strategies will continue to unfold.

Original languageEnglish
Pages (from-to)230-232
Number of pages3
JournalCardiology in Review
Issue number4
StatePublished - 1 Jul 2023
Externally publishedYes


  • Kounis syndrome
  • acute coronary syndrome
  • hypersensitivity
  • inflammatory


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