knot is required for the hypopharyngeal lobe and its derivatives in the Drosophila embryo

Maria Seecoomar, Shradha Agarwal, Kodela Vani, Grace Yang, Jym Mohler

Research output: Contribution to journalArticlepeer-review


The genetic control of segmentation in the Drosophila larval head has been only partially elucidated. We report that the knot (kn) gene of Drosophila is required for the formation of the hypopharyngeal lobe in the germ-band stage embryo and the ventral arms and lateralgrate of the larval head skeleton. Rearrangement mutations of knot disrupt the previously characterized gene, collier, which encodes a COE-family transcription factor. kn is required for the activation of cnc (cap'n'collar, a bZIP homeotic selector gene) in the progenitors of hypopharyngeal lobe. kn is also required for the activation of an EST marker for the cephalic mesoderm, CK01299. Based on the relative expression of kn and the posterior compartment-specific gene hedgehog, we provide additional evidence that in Drosophila, unlike many other insects, the hypopharyngeal lobe arises from part of the mandibular segment. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)209-215
Number of pages7
JournalMechanisms of Development
Issue number1-2
StatePublished - 1 Mar 2000
Externally publishedYes


  • Cephalic mesoderm
  • Drosophila embryogenesis
  • Hypopharyngeal lobe
  • Mandibular segment
  • collier
  • knot


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