@article{e3623489073e4ad3b2d2ed24606887af,
title = "Klinefelter's syndrome in identical twins with the 46,XX chromosome constitution",
abstract = "Two monozygotic twins with male phenotype had a 46,XX karyotype in the buccal mucosa, blood, skin and testis. The data in fourteen previously described phenotypic males with the 46,XX karyotype are reviewed. Although they resemble patients with classic (47,XXY) Klinefelter's syndrome they tend to be better virilized and often have less severe seminiferous tubular damage. Quinacrine staining of interphase and metaphase nuclei of various tissues failed to demonstrate the presence of a Y chromosome. The reason for the development of testicular structures and a male phenotype in these patients remains speculative.",
author = "Nicolis, {G. L.} and Hsu, {L. Y.} and R. Sabetghadam and Kardon, {N. B.} and Chernay, {P. R.} and Mathur, {D. P.} and Rose, {H. G.} and K. Hirschhorn and Gabrilove, {J. L.}",
note = "Funding Information: G. L. NICOLIS, M.D., Ph.D.* L. Y. HSU, M.D. R. SABETGHADAM, M.D. N. B. KARDON, M.D. P. R. CHERNAY, M.D. D. P. MATHUR, M.D. H. G. ROSE, M.D. K. HIRSCHHORN, M.D. J. L. GABRILOVE, M.D. New York, New York From the Departments of Medicine and Pediatrics, The Mount Sinai Hospital and School of Medicine, New York, New York, and the Department of Medicine, Veterans Administration Hospital, Bronx, New York. This study was supported by Grants AM 11855, HD 00210, HD 02552, HD 02754 and FR-71 from the U.S. Public Health Service. R,equests for reprints should be addressed to Dr. Giorgio Nicolis, Department of Medicine, The Mount Sinai Hospital, 1 East 100th Street, New York, New York 10029. Manuscript received June 24, 1971. *Senior Investigator, New York Hea.rt Association.",
year = "1972",
month = apr,
doi = "10.1016/0002-9343(72)90039-3",
language = "English",
volume = "52",
pages = "482--491",
journal = "American Journal of Medicine",
issn = "0002-9343",
publisher = "Elsevier Inc.",
number = "4",
}