Abstract
In this issue of Blood, Liu et al gain an understanding of phenotypic variability in hemoglobinopathies.1 They find that mutations in Krüppel-like factor-1 (KLF1) are significantly more prevalent in patients with β-thalassemia than previously recognized and correlate with a milder phenotype. This supports the emerging concept that monoallelic KLF1 mutations can play a modulatory role in hemoglobinopathies.
Original language | English |
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Pages (from-to) | 672-673 |
Number of pages | 2 |
Journal | Blood |
Volume | 124 |
Issue number | 5 |
DOIs |
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State | Published - 31 Jul 2014 |