Abstract

In this issue of Blood, Liu et al gain an understanding of phenotypic variability in hemoglobinopathies.1 They find that mutations in Krüppel-like factor-1 (KLF1) are significantly more prevalent in patients with β-thalassemia than previously recognized and correlate with a milder phenotype. This supports the emerging concept that monoallelic KLF1 mutations can play a modulatory role in hemoglobinopathies.

Original languageEnglish
Pages (from-to)672-673
Number of pages2
JournalBlood
Volume124
Issue number5
DOIs
StatePublished - 31 Jul 2014

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