Kinetic patterns of liver enzyme elevation with COVID-19 in the USA

Ben L. Da; Robert A. Mitchell; Brian T. Lee; Ponni Perumalswami; Gene Y. Im; Ritu Agarwal; Thomas D. Schiano; Douglas Dieterich; Behnam Saberi

doi:10.1097/MEG.0000000000001792

Kinetic patterns of liver enzyme elevation with COVID-19 in the USA

Ben L. Da, Robert A. Mitchell, Brian T. Lee, Ponni Perumalswami, Gene Y. Im, Ritu Agarwal, Thomas D. Schiano, Douglas Dieterich, Behnam Saberi

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5 Scopus citations

Abstract

COVID-19 is a global pandemic that started in Wuhan, China. COVID-19 related liver enzyme elevations have been described however the clinical presentation, enzyme kinetics, and associated laboratory abnormalities of these patients have not been well described. Five cases of COVID-19 associated liver enzyme elevations are reported here. We found that COVID-19 related liver enzyme elevations occurred in a hepatocellular pattern and persisted throughout the initial hospitalization in all patients. Abnormalities in lactate dehydrogenase and ferritin levels were seen in all five cases. In conclusion, abnormalities in aminotransferase, lactate dehydrogenase, and ferritin levels are commonly seen in COVID-19 related liver injury. Elevated aminotransferase levels often persist throughout the entire hospitalization. However, the clinical course of COVID-19 related liver injury appears benign.

Original language	English
Pages (from-to)	1466-1469
Number of pages	4
Journal	European Journal of Gastroenterology and Hepatology
Volume	32
Issue number	11
DOIs	https://doi.org/10.1097/MEG.0000000000001792
State	Published - 1 Nov 2020

Keywords

COVID-19
hepatitis
pandemics
viral hepatitis

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10.1097/MEG.0000000000001792

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title = "Kinetic patterns of liver enzyme elevation with COVID-19 in the USA",

abstract = "COVID-19 is a global pandemic that started in Wuhan, China. COVID-19 related liver enzyme elevations have been described however the clinical presentation, enzyme kinetics, and associated laboratory abnormalities of these patients have not been well described. Five cases of COVID-19 associated liver enzyme elevations are reported here. We found that COVID-19 related liver enzyme elevations occurred in a hepatocellular pattern and persisted throughout the initial hospitalization in all patients. Abnormalities in lactate dehydrogenase and ferritin levels were seen in all five cases. In conclusion, abnormalities in aminotransferase, lactate dehydrogenase, and ferritin levels are commonly seen in COVID-19 related liver injury. Elevated aminotransferase levels often persist throughout the entire hospitalization. However, the clinical course of COVID-19 related liver injury appears benign.",

keywords = "COVID-19, hepatitis, pandemics, viral hepatitis",

author = "Da, {Ben L.} and Mitchell, {Robert A.} and Lee, {Brian T.} and Ponni Perumalswami and Im, {Gene Y.} and Ritu Agarwal and Schiano, {Thomas D.} and Douglas Dieterich and Behnam Saberi",

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T1 - Kinetic patterns of liver enzyme elevation with COVID-19 in the USA

AU - Da, Ben L.

AU - Mitchell, Robert A.

AU - Lee, Brian T.

AU - Perumalswami, Ponni

AU - Im, Gene Y.

AU - Agarwal, Ritu

AU - Schiano, Thomas D.

AU - Dieterich, Douglas

AU - Saberi, Behnam

PY - 2020/11/1

Y1 - 2020/11/1

N2 - COVID-19 is a global pandemic that started in Wuhan, China. COVID-19 related liver enzyme elevations have been described however the clinical presentation, enzyme kinetics, and associated laboratory abnormalities of these patients have not been well described. Five cases of COVID-19 associated liver enzyme elevations are reported here. We found that COVID-19 related liver enzyme elevations occurred in a hepatocellular pattern and persisted throughout the initial hospitalization in all patients. Abnormalities in lactate dehydrogenase and ferritin levels were seen in all five cases. In conclusion, abnormalities in aminotransferase, lactate dehydrogenase, and ferritin levels are commonly seen in COVID-19 related liver injury. Elevated aminotransferase levels often persist throughout the entire hospitalization. However, the clinical course of COVID-19 related liver injury appears benign.

AB - COVID-19 is a global pandemic that started in Wuhan, China. COVID-19 related liver enzyme elevations have been described however the clinical presentation, enzyme kinetics, and associated laboratory abnormalities of these patients have not been well described. Five cases of COVID-19 associated liver enzyme elevations are reported here. We found that COVID-19 related liver enzyme elevations occurred in a hepatocellular pattern and persisted throughout the initial hospitalization in all patients. Abnormalities in lactate dehydrogenase and ferritin levels were seen in all five cases. In conclusion, abnormalities in aminotransferase, lactate dehydrogenase, and ferritin levels are commonly seen in COVID-19 related liver injury. Elevated aminotransferase levels often persist throughout the entire hospitalization. However, the clinical course of COVID-19 related liver injury appears benign.

KW - COVID-19

KW - hepatitis

KW - pandemics

KW - viral hepatitis

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Kinetic patterns of liver enzyme elevation with COVID-19 in the USA

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Keywords

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