TY - JOUR
T1 - Kidney transplantation in elderly people
T2 - The influence of recipient comorbidity and living kidney donors
AU - Wu, Christine
AU - Shapiro, Ron
AU - Tan, Henkie
AU - Basu, Amit
AU - Smetanka, Cynthia
AU - Morgan, Claire
AU - Shah, Nirav
AU - McCauley, Jerry
AU - Unruh, Mark
PY - 2008/2
Y1 - 2008/2
N2 - OBJECTIVES: To examine the extent to which donor and recipient characteristics were associated with transplant outcomes in elderly kidney transplant recipients. DESIGN: Retrospective review. SETTING: Single university center. PARTICIPANTS: One thousand one hundred two patients, including 266 patients aged 60 and older. MEASUREMENTS: Recipient and donor characteristics and patient and graft outcomes. RESULTS: Of the 1,102 patients included in this study, 266 (25%) were aged 60 and older, and 117 (11%) were aged 67 and older. According to Cox proportional hazards analysis, patient survival was worse in elderly recipients, although the survival outcome in the oldest group (ages 68-86) was comparable with that in their slightly younger peers (ages 61-67). Graft function did not differ according to age. Comorbidity was a significant predictor of patient survival in elderly recipients (hazard ratio (HR)=1.17, 95% confidence interval (CI)=1.03-1.34, P=.02) but not in the subset of elderly recipients of living donor kidneys (HR=1.01, 95% CI=0.8-1.3, P=.9). CONCLUSION: Older adults can achieve good outcomes with kidney transplantation, although in recipients with significant comorbid illness, careful donor selection and selective use of living donors may be vital to achieving good outcomes.
AB - OBJECTIVES: To examine the extent to which donor and recipient characteristics were associated with transplant outcomes in elderly kidney transplant recipients. DESIGN: Retrospective review. SETTING: Single university center. PARTICIPANTS: One thousand one hundred two patients, including 266 patients aged 60 and older. MEASUREMENTS: Recipient and donor characteristics and patient and graft outcomes. RESULTS: Of the 1,102 patients included in this study, 266 (25%) were aged 60 and older, and 117 (11%) were aged 67 and older. According to Cox proportional hazards analysis, patient survival was worse in elderly recipients, although the survival outcome in the oldest group (ages 68-86) was comparable with that in their slightly younger peers (ages 61-67). Graft function did not differ according to age. Comorbidity was a significant predictor of patient survival in elderly recipients (hazard ratio (HR)=1.17, 95% confidence interval (CI)=1.03-1.34, P=.02) but not in the subset of elderly recipients of living donor kidneys (HR=1.01, 95% CI=0.8-1.3, P=.9). CONCLUSION: Older adults can achieve good outcomes with kidney transplantation, although in recipients with significant comorbid illness, careful donor selection and selective use of living donors may be vital to achieving good outcomes.
KW - Elderly
KW - Kidney transplantation
KW - Outcomes
UR - http://www.scopus.com/inward/record.url?scp=38549152739&partnerID=8YFLogxK
U2 - 10.1111/j.1532-5415.2007.01542.x
DO - 10.1111/j.1532-5415.2007.01542.x
M3 - Article
C2 - 18070005
AN - SCOPUS:38549152739
SN - 0002-8614
VL - 56
SP - 231
EP - 238
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
IS - 2
ER -