Kidney injury biomarkers during exposure to tenofovir-based preexposure prophylaxis

Thomas L. Nickolas, Jonathan Barasch, Kenneth K. Mugwanya, Andrea D. Branch, Renee Heffron, Valentine Wanga, Nelly R. Mugo, Allan Ronald, Connie Celum, Deborah Donnell, Jared M. Baeten, Christina M. Wyatt

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


We previously reported a higher incidence of non-albumin proteinuria and a small but significant decline in estimated glomerular filtration rate (eGFR) among HIV-negative adults randomized to emtricitabine/tenofovir disoproxil fumarate preexposure prophylaxis (FTC/TDF PrEP) versus placebo. In a nested case - control study among participants randomized to FTC/TDF PrEP, established kidney injury biomarkers measured at 12 months were not significantly different between participants who subsequently experienced one of these kidney endpoints and randomly selected controls who did not.

Original languageEnglish
Pages (from-to)1147-1149
Number of pages3
Issue number7
StatePublished - 1 Jun 2021


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