Ketanserin inhibits the transient outward current in rabbit ventricular myocytes

Bruno Le Grand; Aline Marty; Francis C. Colpaert; Gareth W. John

doi:10.1097/00005344-199502000-00022

Ketanserin inhibits the transient outward current in rabbit ventricular myocytes

Bruno Le Grand
, Aline Marty
, Francis C. Colpaert
, Gareth W. John

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The effects of ketanserin on the calcium-independent component of the transient outward potassium current (7_to) was investigated in isolated rabbit ventricular myocytes using the whole-cell patch-clamp technique. Ketanserin concentration-dependently (0.1-100 μM) reduced I_to(IC₅₀2.25 ± 2.2 μM; Hill coefficient, n_H0.91), and decreased both the fast and slow 7_toinactiva-tion time constants so that the decay of the peak outward current was significantly accelerated. Our results indicate that, in addition to its antagonist activity on 5HT_2A/Creceptors, ketanserin reduces the calcium-independent component of I_to. Blockade of I_tocould explain the proar-rhythmic properties of ketanserin in vivo.

Original language	English
Pages (from-to)	341-344
Number of pages	4
Journal	Journal of Cardiovascular Pharmacology
Volume	25
Issue number	2
DOIs	https://doi.org/10.1097/00005344-199502000-00022
State	Published - Feb 1995
Externally published	Yes

Keywords

Ketanserin
Rabbit ventricular myocytes
Transient outward current

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10.1097/00005344-199502000-00022

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title = "Ketanserin inhibits the transient outward current in rabbit ventricular myocytes",

abstract = "The effects of ketanserin on the calcium-independent component of the transient outward potassium current (7to) was investigated in isolated rabbit ventricular myocytes using the whole-cell patch-clamp technique. Ketanserin concentration-dependently (0.1-100 μM) reduced Ito(IC502.25 ± 2.2 μM; Hill coefficient, nH0.91), and decreased both the fast and slow 7toinactiva-tion time constants so that the decay of the peak outward current was significantly accelerated. Our results indicate that, in addition to its antagonist activity on 5HT2A/Creceptors, ketanserin reduces the calcium-independent component of Ito. Blockade of Itocould explain the proar-rhythmic properties of ketanserin in vivo.",

keywords = "Ketanserin, Rabbit ventricular myocytes, Transient outward current",

author = "\{Le Grand\}, Bruno and Aline Marty and Colpaert, \{Francis C.\} and John, \{Gareth W.\}",

year = "1995",

month = feb,

doi = "10.1097/00005344-199502000-00022",

language = "English",

volume = "25",

pages = "341--344",

journal = "Journal of Cardiovascular Pharmacology",

issn = "0160-2446",

publisher = "Lippincott Williams and Wilkins",

number = "2",

}

TY - JOUR

T1 - Ketanserin inhibits the transient outward current in rabbit ventricular myocytes

AU - Le Grand, Bruno

AU - Marty, Aline

AU - Colpaert, Francis C.

AU - John, Gareth W.

PY - 1995/2

Y1 - 1995/2

N2 - The effects of ketanserin on the calcium-independent component of the transient outward potassium current (7to) was investigated in isolated rabbit ventricular myocytes using the whole-cell patch-clamp technique. Ketanserin concentration-dependently (0.1-100 μM) reduced Ito(IC502.25 ± 2.2 μM; Hill coefficient, nH0.91), and decreased both the fast and slow 7toinactiva-tion time constants so that the decay of the peak outward current was significantly accelerated. Our results indicate that, in addition to its antagonist activity on 5HT2A/Creceptors, ketanserin reduces the calcium-independent component of Ito. Blockade of Itocould explain the proar-rhythmic properties of ketanserin in vivo.

AB - The effects of ketanserin on the calcium-independent component of the transient outward potassium current (7to) was investigated in isolated rabbit ventricular myocytes using the whole-cell patch-clamp technique. Ketanserin concentration-dependently (0.1-100 μM) reduced Ito(IC502.25 ± 2.2 μM; Hill coefficient, nH0.91), and decreased both the fast and slow 7toinactiva-tion time constants so that the decay of the peak outward current was significantly accelerated. Our results indicate that, in addition to its antagonist activity on 5HT2A/Creceptors, ketanserin reduces the calcium-independent component of Ito. Blockade of Itocould explain the proar-rhythmic properties of ketanserin in vivo.

KW - Ketanserin

KW - Rabbit ventricular myocytes

KW - Transient outward current

UR - https://www.scopus.com/pages/publications/0028959268

U2 - 10.1097/00005344-199502000-00022

DO - 10.1097/00005344-199502000-00022

M3 - Article

C2 - 7752662

AN - SCOPUS:0028959268

SN - 0160-2446

VL - 25

SP - 341

EP - 344

JO - Journal of Cardiovascular Pharmacology

JF - Journal of Cardiovascular Pharmacology

IS - 2

ER -

Ketanserin inhibits the transient outward current in rabbit ventricular myocytes

Abstract

Keywords

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