TY - JOUR
T1 - Ketamine as a novel antidepressant
T2 - From synapse to behavior
AU - Murrough, J. W.
PY - 2012/2
Y1 - 2012/2
N2 - Recent reports of a rapid antidepressant effect of the glutamate N-methyl-D-aspartate (NMDA) receptor antagonist ketamine, even in treatment-resistant populations, have spurred translational therapeutic and neuroscience research aimed at elucidating ketamine's mechanism of action. This article provides a concise overview of research findings that pertain to the effects of low-dose ketamine at the cellular, neurocircuitry, and behavioral levels and describes an integrated model of the action of ketamine in the treatment of depression.
AB - Recent reports of a rapid antidepressant effect of the glutamate N-methyl-D-aspartate (NMDA) receptor antagonist ketamine, even in treatment-resistant populations, have spurred translational therapeutic and neuroscience research aimed at elucidating ketamine's mechanism of action. This article provides a concise overview of research findings that pertain to the effects of low-dose ketamine at the cellular, neurocircuitry, and behavioral levels and describes an integrated model of the action of ketamine in the treatment of depression.
UR - http://www.scopus.com/inward/record.url?scp=84855940822&partnerID=8YFLogxK
U2 - 10.1038/clpt.2011.244
DO - 10.1038/clpt.2011.244
M3 - Article
C2 - 22205190
AN - SCOPUS:84855940822
SN - 0009-9236
VL - 91
SP - 303
EP - 309
JO - Clinical Pharmacology and Therapeutics
JF - Clinical Pharmacology and Therapeutics
IS - 2
ER -