KCa1.1 potassium channels regulate key proinflammatory and invasive properties of fibroblast-like synoviocytes in rheumatoid arthritis

Xueyou Hu, Teresina Laragione, Liang Sun, Shyny Koshy, Karlie R. Jones, Iskander I. Ismailov, Patricia Yotnda, Frank T. Horrigan, Pércio S. Gulko, Christine Beeton

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Fibroblast-like synoviocytes (FLS) play important roles in the pathogenesis of rheumatoid arthritis (RA). Potassium channels have regulatory roles in many cell functions. We have identified the calcium- and voltage-gated KCa1.1 channel (BK, Maxi-K, Slo1, KCNMA1) as the major potassium channel expressed at the plasma membrane of FLS isolated from patients with RA (RA-FLS). We further show that blocking this channel perturbs the calcium homeostasis of the cells and inhibits the proliferation, production of VEGF, IL-8, and pro-MMP-2, and migration and invasion of RA-FLS. Our findings indicate a regulatory role of KCa1.1 channels in RA-FLS function and suggest this channel as a potential target for the treatment of RA.

Original languageEnglish
Pages (from-to)4014-4022
Number of pages9
JournalJournal of Biological Chemistry
Volume287
Issue number6
DOIs
StatePublished - 3 Feb 2012
Externally publishedYes

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