TY - CHAP
T1 - Kaposi’s sarcoma-associated herpesvirus
T2 - Epidemiology and molecular biology
AU - Li, Shasha
AU - Bai, Lei
AU - Dong, Jiazhen
AU - Sun, Rui
AU - Lan, Ke
N1 - Publisher Copyright:
© Springer Nature Singapore Pte Ltd. 2017.
PY - 2017
Y1 - 2017
N2 - Kaposi’s sarcoma-associated herpesvirus (KSHV), also known as Human herpesvirus 8 (HHV-8), is a member of the lymphotropic gammaherpesvirus subfamily and a human oncogenic virus. Since its discovery in AIDS-associated KS tissues by Drs. Yuan Chang and Patrick Moore, much progress has been made in the past two decades. There are four types of KS including classic KS, endemic KS, immunosuppressive therapy-related KS, and AIDS-associated KS. In addition to KS, KSHV is also involved in the development of primary effusion lymphoma (PEL) and certain types of multicentric Castleman’s disease. KSHV manipulates numerous viral proteins to promote the progression of angiogenesis and tumorigenesis. In this chapter, we review the epidemiology and molecular biology of KSHV and the mechanisms underlying KSHV-induced diseases.
AB - Kaposi’s sarcoma-associated herpesvirus (KSHV), also known as Human herpesvirus 8 (HHV-8), is a member of the lymphotropic gammaherpesvirus subfamily and a human oncogenic virus. Since its discovery in AIDS-associated KS tissues by Drs. Yuan Chang and Patrick Moore, much progress has been made in the past two decades. There are four types of KS including classic KS, endemic KS, immunosuppressive therapy-related KS, and AIDS-associated KS. In addition to KS, KSHV is also involved in the development of primary effusion lymphoma (PEL) and certain types of multicentric Castleman’s disease. KSHV manipulates numerous viral proteins to promote the progression of angiogenesis and tumorigenesis. In this chapter, we review the epidemiology and molecular biology of KSHV and the mechanisms underlying KSHV-induced diseases.
KW - KSHV epidemiology
KW - KSHV life cycle
KW - KSHV pathogenesis
KW - Kaposi’s sarcoma-associated herpesvirus
UR - https://www.scopus.com/pages/publications/85032005182
U2 - 10.1007/978-981-10-5765-6_7
DO - 10.1007/978-981-10-5765-6_7
M3 - Chapter
C2 - 29052134
AN - SCOPUS:85032005182
T3 - Advances in Experimental Medicine and Biology
SP - 91
EP - 127
BT - Advances in Experimental Medicine and Biology
PB - Springer New York LLC
ER -