TY - JOUR
T1 - Jun in drosophila development
T2 - Redundant and nonredundant functions and regulation by two mapk signal transduction pathways
AU - Kockel, Lutz
AU - Zeitlinger, Julia
AU - Staszewski, Lena M.
AU - Mlodzik, Marek
AU - Bohmann, Dirk
PY - 1997/7/1
Y1 - 1997/7/1
N2 - Drosophila Jun is shown to be involved in different signal transduction pathways and developmental decisions. Dorsal closure, a morphogenetic process occurring during Drosophila embryogenesis, is regulated by Hemipterous (Hep) and Basket (Bsk), homologs of JNKK and JNK, respectively. Embryos lacking Jun activity exhibit a dorsal closure phenotype, very similar to that of bsk and hep mutants, indicating that Jun is a target of Hep/Bsk signaling. In eye and wing development Jun participates in a separate signaling pathway that is comprised of Ras, Raf, and the ERK-type kinase Rolled. In contrast to the strict requirement for Jun in dorsal closure, its role in the eye is redundant but can be uncovered by mutations in other signaling components. The redundant function of Jun in eye development may contribute to the precision of photoreceptor differentiation and ommatidial assembly.
AB - Drosophila Jun is shown to be involved in different signal transduction pathways and developmental decisions. Dorsal closure, a morphogenetic process occurring during Drosophila embryogenesis, is regulated by Hemipterous (Hep) and Basket (Bsk), homologs of JNKK and JNK, respectively. Embryos lacking Jun activity exhibit a dorsal closure phenotype, very similar to that of bsk and hep mutants, indicating that Jun is a target of Hep/Bsk signaling. In eye and wing development Jun participates in a separate signaling pathway that is comprised of Ras, Raf, and the ERK-type kinase Rolled. In contrast to the strict requirement for Jun in dorsal closure, its role in the eye is redundant but can be uncovered by mutations in other signaling components. The redundant function of Jun in eye development may contribute to the precision of photoreceptor differentiation and ommatidial assembly.
KW - Drosophila development
KW - ERK
KW - JNK
KW - Jun
KW - Signal transduction
KW - Transcription factor
UR - http://www.scopus.com/inward/record.url?scp=0030857388&partnerID=8YFLogxK
U2 - 10.1101/gad.11.13.1748
DO - 10.1101/gad.11.13.1748
M3 - Article
C2 - 9224723
AN - SCOPUS:0030857388
SN - 0890-9369
VL - 11
SP - 1748
EP - 1758
JO - Genes and Development
JF - Genes and Development
IS - 13
ER -