@article{89b97c0c115c4b24af7f9afde34a72df,
title = "Joint multipoint linkage analysis of multivariate qualitative and quantitative trait. II. Alcoholism and event-related potentials",
abstract = "The availability of robust quantitative biological markers that are correlated with qualitative psychiatric phenotypes can potentially improve the power of linkage methods to detect quantitative-trait loci influencing psychiatric disorders. We apply a variance-component method for joint multipoint linkage analysis of multivariate discrete and continuous traits to the extended pedigree data from the Collaborative Study on the Genetics of Alcoholism, in a bivariate analysis of qualitative alcoholism phenotypes and quantitative event-related potentials. Joint consideration of the DSM-IV diagnosis of alcoholism and the amplitude of the P300 component of the Cz event-related potential significantly increases the evidence for linkage of these traits to a chromosome 4 region near the class I alcohol dehydrogenase locus ADH3. A likelihood-ratio test for complete pleiotropy is significant, suggesting that the same quantitative-trait locus influences both risk of alcoholism and the amplitude of the P300 component.",
author = "Williams, {Jeff T.} and Henri Begleiter and Bernice Porjesz and Edenberg, {Howard J.} and Tatiana Foroud and Theodore Reich and Alison Goate and {Van Eerdewegh}, Paul and Laura Almasy and John Blangero",
note = "Funding Information: The development of the statistical methods used in solar was supported by National Institutes of Health grants MH59490, DK44297, HL45522, HL28972, GM31575, and GM18897. Information on the analysis package solar is available at from The Southwest Foundation for Biomedical Research. The Collaborative Study on the Genetics of Alcoholism (COGA) (H. Begleiter, SUNY HSCB, Principal Investigator, T. Reich, Washington University, co–principal investigator) includes six different centers where data collection takes place. The six sites and Principal Investigator and Coinvestigators are Indiana University (J. Nurnberger, Jr., T.-K. Li, P. M. Conneally, and H. Edenberg); University of Iowa (R. Crowe and S. Kuperman); University of California at San Diego and Scripps Institute (M. Schuckit and F. E. Bloom); University of Connecticut (V. Hesselbrock); State University of New York, Health Science Center at Brooklyn (H. Begleiter and B. Porjesz); and Washington University, St. Louis (T. Reich, C. R. Cloninger, and J. Rice). This national collaborative study is supported by the National Institute on Alcohol Abuse and Alcoholism, through U.S. Public Health Service grants NIAAA U10AA08401, U10AA08402, and U10AA08403. ",
year = "1999",
doi = "10.1086/302571",
language = "English",
volume = "65",
pages = "1148--1160",
journal = "American Journal of Human Genetics",
issn = "0002-9297",
publisher = "Cell Press",
number = "4",
}