JNK signaling in apoptosis

D. N. Dhanasekaran, E. P. Reddy

Research output: Contribution to journalReview articlepeer-review

1218 Scopus citations

Abstract

Jun N-terminal kinases or JNKs play a critical role in death receptor-initiated extrinsic as well as mitochondrial intrinsic apoptotic pathways. JNKs activate apoptotic signaling by the upregulation of pro-apoptotic genes through the transactivation of specific transcription factors or by directly modulating the activities of mitochondrial pro- and antiapoptotic proteins through distinct phosphorylation events. This review analyses our present understanding of the role of JNK in apoptotic signaling and the various mechanisms by which JNK promotes apoptosis.

Original languageEnglish
Pages (from-to)6245-6251
Number of pages7
JournalOncogene
Volume27
Issue number48
DOIs
StatePublished - 20 Oct 2008
Externally publishedYes

Keywords

  • Apoptosis
  • Cell death
  • JNK
  • MAP3K
  • MKK4
  • MKK7

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