J-curve association between alcohol intake and varicose veins in Japan: The Shimane CoHRE Study

Kunie Kohno, Hiroyuki Niihara, Tsuyoshi Hamano, Miwako Takeda, Yusei Nakagawa, Kuninori Shiwaku, Toru Nabika, Bengt Zöller, Xinjun Li, Kristina Sundquist, Jan Sundquist, Eishin Morita

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The effect of alcohol intake on varicose veins (VV) has not been determined by its consumption level. The aim of this study was to investigate the association between alcohol intake and VV in an elderly general population. Using a cross-sectional approach, the Shimane CoHRE Study data, comprising a total of 1060 participants, were analyzed. By multivariate regression analysis adjusted with basic characteristics, past work history, lifestyle-related factors and medical history, compared with non-drinkers, mild drinkers (<20.0 g/day) showed a significantly lower adjusted odds ratio (aOR) of VV (aOR = 0.64, P = 0.036). In a similar way, regular drinkers (1–5 days/week) showed a significantly lower aOR of VV when compared with occasional drinkers (aOR = 0.57, P = 0.032). VV and alcohol intake showed J-curve relationships. In a stratified analysis by alcohol consumption levels, the association of smoking and VV were also observed in moderate to heavy drinkers and habitual drinkers. These findings can provide better understanding of pathophysiological mechanism and be used for evidence-based patient education.

Original languageEnglish
Pages (from-to)902-906
Number of pages5
JournalJournal of Dermatology
Volume46
Issue number10
DOIs
StatePublished - 1 Oct 2019

Keywords

  • alcohol drinking
  • epidemiology
  • lifestyle
  • varicose veins
  • venous thromboembolism

Fingerprint

Dive into the research topics of 'J-curve association between alcohol intake and varicose veins in Japan: The Shimane CoHRE Study'. Together they form a unique fingerprint.

Cite this