Isolation from BALB/c mouse cells of a structural polypeptide of a third endogenous type C virus

John R. Stephenson; Steven R. Tronick; Stuart A. Aaronson

doi:10.1016/0092-8674(74)90049-X

Isolation from BALB/c mouse cells of a structural polypeptide of a third endogenous type C virus

John R. Stephenson, Steven R. Tronick, Stuart A. Aaronson

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

A 12,000 molecular weight type C viral polypeptide, p12, has been isolated from BALB/c mouse cells. This polypeptide is shown to be immunologically distinct from the p12 antigens of two previously described endogenous viruses of BALB/c cells. It is, however, indistinguishable from a viral antigen expressed in NIH Swiss mouse cells and present in type C viruses isolated from NIH Swiss mice. The expression of endogenous viruses containing each of the three distinguishable p12 antigens is shown to be differentially affected by two classes of chemical inducers, halogenated pyrimidines and inhibitors of protein synthesis. The present findings thus provide evidence for the existence of genetic information of three distinguishable endogenous viruses within cells of the BALB/c strain.

Original language	English
Pages (from-to)	347-353
Number of pages	7
Journal	Cell
Volume	3
Issue number	4
DOIs	https://doi.org/10.1016/0092-8674(74)90049-X
State	Published - Dec 1974
Externally published	Yes

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@article{d11c79bdbff94d63ae774e0785555c9f,

title = "Isolation from BALB/c mouse cells of a structural polypeptide of a third endogenous type C virus",

abstract = "A 12,000 molecular weight type C viral polypeptide, p12, has been isolated from BALB/c mouse cells. This polypeptide is shown to be immunologically distinct from the p12 antigens of two previously described endogenous viruses of BALB/c cells. It is, however, indistinguishable from a viral antigen expressed in NIH Swiss mouse cells and present in type C viruses isolated from NIH Swiss mice. The expression of endogenous viruses containing each of the three distinguishable p12 antigens is shown to be differentially affected by two classes of chemical inducers, halogenated pyrimidines and inhibitors of protein synthesis. The present findings thus provide evidence for the existence of genetic information of three distinguishable endogenous viruses within cells of the BALB/c strain.",

author = "Stephenson, {John R.} and Tronick, {Steven R.} and Aaronson, {Stuart A.}",

note = "Funding Information: The authors thank Roberta K. Reynolds and Jeanne M. LeBon for their excellent technical assistance. This work was supported by a contract from the Special Virus Cancer Program of the National Cancer Institute.",

year = "1974",

month = dec,

doi = "10.1016/0092-8674(74)90049-X",

language = "English",

volume = "3",

pages = "347--353",

journal = "Cell",

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TY - JOUR

T1 - Isolation from BALB/c mouse cells of a structural polypeptide of a third endogenous type C virus

AU - Stephenson, John R.

AU - Tronick, Steven R.

AU - Aaronson, Stuart A.

N1 - Funding Information: The authors thank Roberta K. Reynolds and Jeanne M. LeBon for their excellent technical assistance. This work was supported by a contract from the Special Virus Cancer Program of the National Cancer Institute.

PY - 1974/12

Y1 - 1974/12

N2 - A 12,000 molecular weight type C viral polypeptide, p12, has been isolated from BALB/c mouse cells. This polypeptide is shown to be immunologically distinct from the p12 antigens of two previously described endogenous viruses of BALB/c cells. It is, however, indistinguishable from a viral antigen expressed in NIH Swiss mouse cells and present in type C viruses isolated from NIH Swiss mice. The expression of endogenous viruses containing each of the three distinguishable p12 antigens is shown to be differentially affected by two classes of chemical inducers, halogenated pyrimidines and inhibitors of protein synthesis. The present findings thus provide evidence for the existence of genetic information of three distinguishable endogenous viruses within cells of the BALB/c strain.

AB - A 12,000 molecular weight type C viral polypeptide, p12, has been isolated from BALB/c mouse cells. This polypeptide is shown to be immunologically distinct from the p12 antigens of two previously described endogenous viruses of BALB/c cells. It is, however, indistinguishable from a viral antigen expressed in NIH Swiss mouse cells and present in type C viruses isolated from NIH Swiss mice. The expression of endogenous viruses containing each of the three distinguishable p12 antigens is shown to be differentially affected by two classes of chemical inducers, halogenated pyrimidines and inhibitors of protein synthesis. The present findings thus provide evidence for the existence of genetic information of three distinguishable endogenous viruses within cells of the BALB/c strain.

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U2 - 10.1016/0092-8674(74)90049-X

DO - 10.1016/0092-8674(74)90049-X

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AN - SCOPUS:0016313750

SN - 0092-8674

VL - 3

SP - 347

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JO - Cell

JF - Cell

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ER -

Isolation from BALB/c mouse cells of a structural polypeptide of a third endogenous type C virus

Abstract

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