Islet Cell Tumors of the Pancreas

Sunil Amin, Michelle Kang Kim

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

Islet cell tumors of the pancreas, also known as pancreatic neuroendocrine tumors, constitute less than 5% of pancreatic tumors, and 7% of all neuroendocrine tumors. Most are non-functional, and patients often present with metastatic disease. Functional tumors present with distinct clinical syndromes. Accurate staging is critical as surgery is both the cornerstone of treatment, and the only hope for cure. Medical management involves treating the manifestations of hormonal excess, and using somatastatin analogues when appropriate. Systemic chemotherapy, targeted molecular therapy, and peptide receptor radiotherapy may be used for refractory disease in lieu of or as an adjunct to surgery.

Original languageEnglish
Pages (from-to)83-100
Number of pages18
JournalGastroenterology Clinics of North America
Volume45
Issue number1
DOIs
StatePublished - 1 Mar 2016

Keywords

  • Islet cell tumor
  • Pancreas
  • Pancreas cancer
  • Pancreatic neuroendocrine tumors (PNET)
  • Targeted molecular therapy

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