Is There a Role for Desensitization in Intestinal Transplantation?

Andrew D. Santeusanio, Jang Moon, Vinay Nair, Kishore R. Iyer

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Human leukocyte antigen allosensitization prior to transplant can increase the risk of early graft loss and prolong waitlist times for intestinal transplant candidates. Desensitization offers a potential therapeutic option to reduce the quantity of preformed antibodies prior to organ allocation and facilitate transplantation with a more immunologically compatible donor allograft. However, there remains a paucity of data to guide the use of desensitization in the setting of intestinal transplantation. As a result, in this review we evaluate the existing literature supporting the role of desensitization therapy in intestinal transplant, describe our own experience with the implementation of a risk-stratified desensitization protocol, and finally explore barriers and unanswered questions that continue to limit the widespread adoption of desensitization as a management strategy for highly sensitized intestinal transplant candidates.

Original languageEnglish
Pages (from-to)275-278
Number of pages4
JournalProgress in Transplantation
Volume29
Issue number3
DOIs
StatePublished - 1 Sep 2019

Keywords

  • bortezomib
  • graft survival
  • immunologic desensitization
  • intestinal transplantation

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