Abstract
Objective: Based on emerging preclinical findings suggesting that paternal smoking at conception may be a risk for ADHD in the offspring, we investigated whether a similar effect can be observed in humans. Method: We analyzed data from an opportunistic dataset of girl probands with (N = 140) and without (N = 122) ADHD with available information on paternal smoking at conception. Data were analyzed using Pearson’s chi-square tests and multiple logistic regression. Results: ADHD probands had a significantly higher rate of paternal smoking at conception than controls (35% vs. 23%, χ2 = 3.82, p =.05) with a significant odds ratio of 1.5. However, the association lost significance after controlling for paternal ADHD, most likely due to limited statistical power. Conclusion: While preliminary, findings suggest that paternal smoking at conception may be a risk factor for ADHD in the offspring.
Original language | English |
---|---|
Pages (from-to) | 1493-1496 |
Number of pages | 4 |
Journal | Journal of Attention Disorders |
Volume | 24 |
Issue number | 11 |
DOIs | |
State | Published - 1 Sep 2020 |
Externally published | Yes |
Keywords
- ADHD
- nicotine
- paternal smoking
- pregnancy