TY - JOUR
T1 - Is it possible to develop a “universal” influenza virus vaccine?
T2 - Potential target antigens and critical aspects for a universal influenza vaccine
AU - Krammer, Florian
AU - García-Sastre, Adolfo
AU - Palese, Peter
N1 - Publisher Copyright:
© 2018 Cold Spring Harbor Laboratory Press; all rights reserved.
PY - 2018/7
Y1 - 2018/7
N2 - Influenza viruses cause seasonal epidemics as well as pandemics and are a significant concern for human health. Current influenza virus vaccines show efficacy when they are antigenically well matched to circulating strains. Seasonal influenza viruses undergo antigenic drift at a high rate and, therefore, current vaccines have to be reformulated and read-ministered on an annual basis. Mismatches between vaccine strains and circulating strains frequently occur, significantly decreasing vaccine efficacy. In addition, current seasonal influenza virus vaccines have limited efficacy against newly emerging pandemic viruses. A universal influenzavirus vaccine that induces long-term protection against all influenzavirus strains would abolish the need for annual readministration of seasonal influenza virus vaccines and would significantly enhance our pandemic preparedness. Here we discuss the characteristics of universal influenza virus vaccines, their potential target antigens, and critical aspects to consider on the path to successfully developing such vaccines.
AB - Influenza viruses cause seasonal epidemics as well as pandemics and are a significant concern for human health. Current influenza virus vaccines show efficacy when they are antigenically well matched to circulating strains. Seasonal influenza viruses undergo antigenic drift at a high rate and, therefore, current vaccines have to be reformulated and read-ministered on an annual basis. Mismatches between vaccine strains and circulating strains frequently occur, significantly decreasing vaccine efficacy. In addition, current seasonal influenza virus vaccines have limited efficacy against newly emerging pandemic viruses. A universal influenzavirus vaccine that induces long-term protection against all influenzavirus strains would abolish the need for annual readministration of seasonal influenza virus vaccines and would significantly enhance our pandemic preparedness. Here we discuss the characteristics of universal influenza virus vaccines, their potential target antigens, and critical aspects to consider on the path to successfully developing such vaccines.
UR - http://www.scopus.com/inward/record.url?scp=85049511074&partnerID=8YFLogxK
U2 - 10.1101/cshperspect.a028845
DO - 10.1101/cshperspect.a028845
M3 - Article
C2 - 28663209
AN - SCOPUS:85049511074
SN - 1943-0264
VL - 10
JO - Cold Spring Harbor perspectives in biology
JF - Cold Spring Harbor perspectives in biology
IS - 7
M1 - a028845
ER -